Body fat content and 25-hydroxyvitamin D levels in healthy women
Body fat content and 25-hydroxyvitamin D levels in healthy women
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DOI：
10.1210/jc.2002-020978
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发表时间：
2003-01-01
影响因子：
5.8
通讯作者：
Aloia, JF
中科院分区：
文献类型：
--
作者：
Arunabh, S;Pollack, S;Aloia, JF
肥胖与维生素D内分泌系统的改变有关。病态肥胖者血清25-羟维生素D（25-OHD）水平较低可能是继发于脂肪量增加导致的组织分布改变。因此，预计病态肥胖个体需要比一般人群更高剂量的维生素D补充剂。然而，在评估一般人群的维生素D需求量时，是否应考虑肥胖（或体脂百分比）仍是未知数。为了研究健康女性体内25-OHD水平与体脂含量百分比之间的关系，我们研究了410名年龄在20至80岁之间的健康女性，体重指数范围为17至30 kg/m2。我们分析了血清25-OHD水平与双能X线吸收法测量的体脂百分比之间的相关性。我们还分析了季节，膳食维生素D摄入量，年龄和种族对这种关系的影响。血清25-OHD水平与体脂百分比呈负相关。在调整种族、年龄、季节和膳食维生素D摄入量后，相关性为-0.13（P = 0.013）。在多元逐步回归分析中，发现种族和季节对血清25-OHD有重大影响（累积R-2 = 0.34），而体脂百分比虽然适度（额外R-2 = 0.02），但对血清25-OHD水平也有独立的统计学显著影响。我们的结论是，身体脂肪含量的百分比是负相关的健康女性血清25-OHD水平。
Obesity is associated with alterations in the vitamin D endocrine system. Lower levels of serum 25-hydroxyvitamin D (25-OHD) in morbidly obese individuals may be secondary to an alteration in tissue distribution resulting from an increase in adipose mass. Therefore, morbidly obese individuals are expected to need higher doses of vitamin D supplementation than the general population. However, it is still unknown whether adiposity (or percentage body fat) should be taken into consideration while assessing vitamin D requirements in the general population. To study the relationship between 25-OHD levels and percentage body fat content in healthy women, we studied 410 healthy women between 20 and 80 yr of age with body mass index ranging from 17 to 30 kg/m(2). We analyzed the correlation between serum 25-OHD level and percentage body fat measured by dual energy x-ray absorptiometry. We also analyzed the influence of season, dietary vitamin D intake, age, and race on this relationship. The levels of serum 25-OHD inversely correlated with percentage body fat. The correlation was -0.13 (P = 0.013) after adjusting for race, age, season, and dietary vitamin D intake. In a multiple stepwise regression, race and season were found to have a major influence on serum 25-OHD (cumulative R-2 = 0.34), and percentage body fat, although modest (additional R-2 = 0.02), also had an independent statistically significant influence on serum 25-OHD levels. We conclude, percentage body fat content is inversely related to the serum 25-OHD levels in healthy women.