The Priamo Study: A Multicenter Assessment of Nonmotor Symptoms and Their Impact on Quality of Life in Parkinson's Disease
The Priamo Study: A Multicenter Assessment of Nonmotor Symptoms and Their Impact on Quality of Life in Parkinson's Disease
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DOI：
10.1002/mds.22643
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发表时间：
2009-08-15
影响因子：
8.6
通讯作者：
Del Dotto, Paolo
中科院分区：
文献类型：
--
作者：
Barone, Paolo;Antonini, Angelo;Del Dotto, Paolo
我们对55个意大利中心12个月内招募的1，072名帕金森病（PD）患者进行了一项多中心调查，采用半结构化访谈，以评估非运动症状（NMS）的患病率及其与认知障碍的相关性。以及对患者生活质量（QoL）的影响。我们发现，98.6%的PD患者报告存在NMS。最常见的是疲劳（58%）、焦虑（56%）、腿痛（39%）、失眠（37%）、尿急和尿急（35%）、流口水和难以集中注意力（31%）。每例患者的NMS平均数为7.8（范围，0-32）。精神领域的NMS最常见（67%）。NMS的发生频率沿着病程和病情加重而增加。认知障碍患者更频繁地报告冷漠、注意力/记忆力缺陷和精神症状。冷漠是与PDQ-39评分较差相关的症状，但疲劳、注意力/记忆力和精神症状的存在也对QoL产生负面影响。这些发现进一步支持NMS在PD临床框架中的关键作用，以及在临床试验中使用专用量表专门解决这些问题的必要性。(C)2009运动障碍协会
We performed a multicenter survey using a semi-structured interview in 1,072 consecutive patients with Par kinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment. and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (39%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0-32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ-39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. (C) 2009 Movement Disorder Society