Selection for mutational robustness in finite populations
Selection for mutational robustness in finite populations
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DOI：
10.1016/j.jtbi.2006.06.020
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发表时间：
2006-11-21
影响因子：
2
通讯作者：
Wilke, Claus O.
中科院分区：
文献类型：
--
作者：
Forster, Robert;Adami, Christoph;Wilke, Claus O.
我们研究了一个有限种群的RNA序列在一个神经网络上复制的进化动力学。尽管缺乏可行的序列之间的差异适应性，我们观察到典型的适应性进化，如增加的平均适应性随着时间的推移和间断平衡过渡，初始突变选择平衡后，已经达到。我们发现，约30或更大的人口规模和突变率的乘积足以产生突变鲁棒性的选择压力，即使人口规模比人口所居住的神经网络小几个数量级。我们的研究结果表明，准种效应和中性漂移可以同时发生，并且每一个的相对重要性是由人口规模和突变率的产品。(c)2006爱思唯尔有限公司保留所有权利。
We investigate the evolutionary dynamics of a finite population of RNA sequences replicating on a neutral network. Despite the lack of differential fitness between viable sequences, we observe typical properties of adaptive evolution, such as increase of mean fitness over time and punctuated-equilibrium transitions, after initial mutation-selection balance has been reached. We find that a product of population size and mutation rate of approximately 30 or larger is sufficient to generate selection pressure for mutational robustness, even if the population size is orders of magnitude smaller than the neutral network on which the population resides. Our results show that quasispecies effects and neutral drift can occur concurrently, and that the relative importance of each is determined by the product of population size and mutation rate. (c) 2006 Elsevier Ltd. All rights reserved.