Cerebral Blood Flow Regulation Under the Conditions of Arterial Hypoxia
Cerebral Blood Flow Regulation Under the Conditions of Arterial Hypoxia
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动脉缺氧条件下脑血流的调节
DOI：
10.1007/978-3-642-67020-6_18
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发表时间：
1978
影响因子：
3.3
通讯作者：
J. Grote
中科院分区：
文献类型：
--
作者：
J. Grote
明显的动脉缺氧导致脑血管阻力降低，全脑血流量和局部血流量增加。在正常动脉血压和正常酸碱状态下，当动脉血氧分压降至约50 mm Hg以下时，这两个参数的变化就开始了。与此同时，脑静脉血中的氧分压达到约28毫米汞柱以下。不同的作者[23，28，30，31，33]报道，脑血流对PaO2降低的反应是达到这些氧分压的阈值。由于Noell和Schneider在[30，31]中观察到，在不同原因引起脑组织供氧不足的情况下，当脑静脉血氧分压在25-28 mm Hg之间几乎不变时，总的脑血流量总是增加，因此脑静脉血氧分压的阈值被赋予了特殊的意义。
Pronounced arterial hypoxia induces a decrease of cerebrovascular resistance and an increase of total and regional cerebral blood flow. Under the conditions of normal arterial blood pressure and normal acid base status, the changes of both parameters commence when the oxygen tension in the arterial blood decreases below approximately 50 mm Hg. At the same time, the oxygen tension in the cerebral venous blood reaches values below approximately 28 mm Hg. Different authors [23, 28, 30, 31, 33] reported that cerebral blood flow responses to PaO2 decrease are threshold at these oxygen tensions. The threshold oxygen tension of cerebral venous blood was accorded a special significance because Noell and Schneider [30, 31] observed that, under the conditions of insufficient oxygen supply in the brain tissue induced by different causes, an increase of the total cerebral blood flow always occurred when cerebral venous oxygen tension values were nearly constant between 25–28 mm Hg.