Oral ketamine in paediatric non-convulsive status epilepticus
Oral ketamine in paediatric non-convulsive status epilepticus
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DOI：
10.1016/s1059-1311(03)00028-1
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发表时间：
2003-10-01
影响因子：
3
通讯作者：
Dan, B
中科院分区：
文献类型：
--
作者：
Mewasingh, LD;Sékhara, T;Dan, B
在儿童中，非惊厥性癫痫持续状态（NCSE）是罕见且难以治疗的。对类固醇和GABA能药物的反应是可变的，通常随着NCSE持续时间的增加而降低。我们提出了我们的经验，口服氯胺酮，NMDA受体拮抗剂，给予5名儿童严重癫痫（Lennox-Gastaut综合征，肌阵挛-失稳性癫痫，进行性肌阵挛性癫痫和假性Lennox综合征）在NCSE发作。在临床和脑电图上，所有病例均在开始氯胺酮治疗后24-48小时内记录NCSE消退。未观察到明显的副作用。(C)2003年，由爱思唯尔科技有限公司出版，版权所有。
In children, non-convulsive status epilepticus (NCSE) is rare and difficult to treat. Response to steroids and GABAergic medication is variable and often decreases with increasing duration of NCSE. We present our experience with oral ketamine, an NMDA-receptor antagonist, administered to five children with severe epilepsy (Lennox-Gastaut Syndrome, myoclonic-astatic epilepsy, progressive myoclonic epilepsy and Pseudo-Lennox Syndrome) during an episode of NCSE. Resolution of NCSE was documented in all cases clinically and electroencephalographically within 24-48 hours of starting ketamine. No significant side effects were noted. (C) 2003 BEA Trading Ltd. Published by Elsevier Science Ltd. All rights reserved.