Contact allergy to o-cresol--a sensitizer in phenol-formaldehyde resin.
Contact allergy to o-cresol--a sensitizer in phenol-formaldehyde resin.
复制标题
对邻甲酚（酚醛树脂中的一种敏化剂）接触过敏。
DOI：
10.1053/ajcd.2002.36637
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
E. Zimerson
中科院分区：
文献类型：
--
作者：
M. Bruze;E. Zimerson
BACKGROUND
In patients hypersensitive to phenol formaldehyde resin (PFR) it is, for therapeutic and preventive reasons, important to know the identity of the primary sensitizing substances, their sensitizing capacity, as well as their cross-reaction patterns. When elucidating the issue of cross reactivity in patients with contact allergy to simple methylol phenols (MP), o-cresol was shown to be a contact sensitizer. Besides cross reactivity, contamination of one or more MP(s) in o-cresol as well as o-cresol being a sensitizer of its own in PFR were possible explanations of the simultaneous positive patch test reactions to MP and o-cresol.
OBJECTIVE
The aim of this study was to investigate if the simultaneous allergic reactions to PFR and o-cresol could be explained by the presence of this substance in PFR.
METHODS
Patch testing, high-pressure liquid chromatography (HPLC), nuclear magnetic resonance spectrometry (NMR), gas chromatography (GC), and mass spectrometry (MS) were used.
RESULTS
o-Cresol was isolated from the specific PFR used in our standard patch test series and identified. The concentration in the resin was 0.066% wt/wt.
CONCLUSION
The current study establishes o-cresol as a contact sensitizer in a PFR. The observed reactions to o-cresol could be on the basis of cross reactivity or primary sensitization.
