IMMUNOHISTOCHEMICAL LOCALIZATION OF VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) IN MERKEL CELLS OF VARIOUS MAMMALS - EVIDENCE FOR A NEUROMODULATOR FUNCTION OF THE MERKEL CELL
IMMUNOHISTOCHEMICAL LOCALIZATION OF VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) IN MERKEL CELLS OF VARIOUS MAMMALS - EVIDENCE FOR A NEUROMODULATOR FUNCTION OF THE MERKEL CELL
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DOI：
10.1111/1523-1747.ep12519966
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发表时间：
1983-01-01
影响因子：
6.5
通讯作者：
REINECKE, M
中科院分区：
文献类型：
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作者：
HARTSCHUH, W;WEIHE, E;REINECKE, M
由于甲硫氨酸脑啡肽样物质仅存在于某些啮齿动物的Merkel细胞中，而猫、狗、猪和人的Merkel细胞中没有发现甲硫氨酸脑啡肽样物质，因此用不同的抗血清对这些物种的Merkel细胞进行了免疫组织化学分析，以观察与甲硫氨酸脑啡肽不同的神经肽的存在。在所研究的所有物种的不同部位，Merkel细胞仅对血管活性肠多肽(VIP)有免疫反应，而不对所用的任何其他抗血清有免疫反应。在哺乳动物的默克尔细胞中，神经肽的产生与甲硫氨酸脑啡肽不同。显然，Merkel细胞-轴突复合体代表了一个复杂的调节系统，涉及一种假定的受体或调节器功能，由此Merkel细胞可能通过释放神经肽(VIP或甲硫氨酸脑啡肽样物质)来影响感觉神经末梢的阈值。
Since met-enkephalin-like substance has been demonstrated only in Merkel cells of some rodents but not of cat, dog, pig and humans, Merkel cells of these species were analyzed by immunohistochemistry using a variety of different antisera for the occurrence of neuropeptides different from met-enkephalin. In various locations of all species investigated Merkel cells were immunoreactive exclusively to vasoactive intestinal polypeptide (VIP) but not to any of the other antisera used. In mammalian Merkel cells, neuropeptides occur that are different from met-enkephalin. Evidently the Merkel cell-axon complex represents a complex regulatory system involving a presumptive receptor or modulator function whereby the Merkel cell may influence the threshold of the sensory nerve ending via release of a neuropeptide (VIP- or met-enkephalin-like material).