Universes collide: combining immunotherapy with targeted therapy for cancer.
Universes collide: combining immunotherapy with targeted therapy for cancer.
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DOI：
10.1158/2159-8290.cd-14-0477
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发表时间：
2014-12
期刊：
影响因子：
28.2
通讯作者：
Flaherty KT
中科院分区：
文献类型：
--
作者：
Wargo JA;Cooper ZA;Flaherty KT
There have been significant advances in the past several years with regard to targeted therapy and immunotherapy for cancer. This is highlighted in melanoma, where treatment with targeted therapy (against the BRAF oncogene) results in responses in the majority of patients, though duration of response is limited. In contrast, treatment with immunotherapy results in a lower response rate, but ones that tend to be more durable. Insights regarding mechanisms of response and potential synergy between these treatment strategies for melanoma are a focus of this review, with opportunities to extend these insights to the treatment of other cancers.
