Acute gastrointestinal manifestations associated with use of crack
Acute gastrointestinal manifestations associated with use of crack
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DOI：
10.1053/ajem.2001.20010
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发表时间：
2001-01-01
影响因子：
3.6
通讯作者：
Evans, T
中科院分区：
文献类型：
--
作者：
Muñiz, AE;Evans, T
快克是可卡因的游离碱形式，会导致肺部、心脏、产科、神经系统、肌肉骨骼和胃肠道并发症。随着可卡因使用的普及，可卡因相关急诊科（ED）的访问量、住院人数和死亡人数应随之增加。我们报告了3例因吸食可卡因后急性腹痛而到达急诊室的患者。这些患者需要手术矫正肠穿孔。虽然肠道缺血的确切病理生理机制尚不清楚，但可卡因阻断去甲肾上腺素的再摄取，导致肠系膜血管收缩和局灶性组织缺血，可能导致穿孔。可卡因吸食与胃肠道穿孔的时间关系使我们推测，可能与可卡因相关的缺血性事件是这些患者穿孔的原因。检查腹痛患者的医生应该意识到可卡因潜在的胃肠道并发症，当可卡因滥用者出现腹痛时，应考虑肠缺血。[J] .中华医学杂志2001；19:61-63。版权所有(C) 2001由w.b.，桑德斯公司)。
Crack, the free base form of cocaine, causes pulmonary, cardiac, obstetric, neurologic, muskuloskeletal, and gastrointestinal complications. As the popularity for crack use increases, it follows that the number of cocaine-related emergency department (ED) visits, hospitalizations, and deaths should increase, We report 3 cases of patients arriving to the ED with acute onset of abdominal pain after smoking crack. These patients required surgical correction of their intestinal perforations. Although the exact pathophysiology of intestinal ischemia is not known, cocaine blocks the reuptake of norepinephrine, which leads to mesenteric vasoconstriction and focal tissue ischemia that may lead to perforation. The chronologic relationship of crack consumption to gastrointestinal perforation leads us to surmise that a possible crack-related ischemic event is the cause of perforation in these patients, Physicians examining patients with abdominal pain should be aware of the potential gastrointestinal complications of crack and consider bowel ischemia whenever a cocaine abuser presents with abdominal pain. (Am J Emerg Med 2001; 19:61-63. Copyright (C) 2001 by W.B, Saunders Company).