Signaling by fibroblast growth factors: the inside story.
Signaling by fibroblast growth factors: the inside story.
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DOI：
10.1126/stke.2001.106.pe37
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发表时间：
2001-10-30
期刊：
影响因子：
--
通讯作者：
Goldfarb, M
中科院分区：
文献类型：
--
作者：
Goldfarb, M
多肽生长因子与细胞表面受体的胞外结构域结合，触发受体内在或受体相关蛋白激酶的激活。尽管这一中心论点已被广泛接受，但成纤维细胞生长因子 (FGF) 等蛋白质家族十多年来一直吸引着“反文化”研究，寻找 FGF 在细胞内的直接作用。 Goldfarb 讨论了在最近两篇报道 FGF 和 FGF 样蛋白特定细胞内靶标的出版物的帮助下，寻找替代信号通路如何成为主流。
Polypeptide growth factors bind to the extracellular domains of cell surface receptors, triggering activation of receptor-intrinsic or receptor-associated protein kinases. Although this central thesis is widely accepted, one family of proteins, the fibroblast growth factors (FGFs), have for more than a decade attracted a research "counterculture" looking for direct FGF actions inside cells. Goldfarb discusses how the search for alternative signaling pathways is moving mainstream with the help of two recent publications reporting specific intracellular targets for FGF and FGF-like proteins.