Comparison of behavioral and psychological symptoms in early-onset and late-onset Alzheimer's disease
Comparison of behavioral and psychological symptoms in early-onset and late-onset Alzheimer's disease
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DOI：
10.1002/gps.1760
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发表时间：
2007-09-01
影响因子：
4
通讯作者：
Tanabe, Hirotaka
中科院分区：
文献类型：
--
作者：
Toyota, Yasutaka;Ikeda, Manabu;Tanabe, Hirotaka
研究背景早发型阿尔茨海默病（EO-AD）与晚发型阿尔茨海默病（LO-AD）相比，在临床特征上存在一定的病理学差异。快速进展，更严重的语言问题或视觉空间功能障碍更常见于EO-AD患者。然而，关于这两组之间行为和心理症状差异的报道很少。目的探讨EO-AD与LO-AD患者行为症状的差异。方法将307例AD患者分为EO-AD组（46例）和LO-AD组（261例）。在第一次医学评估时进行综合评估，包括神经精神量表（NPI）。结果EO-AD组和LO-AD组的NPI总分（EO-AD：10.3 ± 10.9，LO-AD：17.8 ± 17.0，p = 0.004）和出现NPI各分量表评分的患者数（妄想：EO-AD：13.0%，LO-AD：50.6%，p <0.001）差异有统计学意义。两组认知功能和痴呆严重程度无差异。结论EO-AD患者在首次医学评估时的行为和心理症状相对较少。版权所有（c）2007约翰威利父子有限公司。
Background When comparing with early-onset Alzheimer's disease (EO-AD) and late-onset Alzheimer's disease (LO-AD), some symptomatological differences in clinical features can be seen between them. Rapid progression, more severe language problems or visuospatial dysfunction occur more often in EO-AD patients. However, there have been very few reports about the differences in behavioral and psychological symptoms between these two groups. Aim The aim of this study was to demonstrate the differences in behavioral symptoms between EO-AD and LO-AD groups. Method Three hundred and seven consecutive outpatients with AD were put into an EO-AD group (46 patients) or a LO-AD group (261 patients). Comprehensive assessment batteries, including the Neuropsychiatric Inventory (NPI), were administered at the first medical assessment. Results Significant differences were found between the EO-AD and LO-AD groups in terms of NPI total score (EO-AD: 10.3 10.9, LO-AD: 17.8 17.0, p = 0.004) and number of patients who experienced each NPI subscale score (delusion; EO-AD: 13.0%, LO-AD: 50.6%, p < 0.00 1). There were no differences in cognitive functions or dementia severity between two groups. Conclusion In EO-AD, behavioral and psychological symptoms are relatively fewer than LO-AD at the first medical assessment. Copyright (c) 2007 John Wiley & Sons, Ltd.