MIGRATION AND HIV-1 SEROPREVALENCE IN A RURAL UGANDAN POPULATION
MIGRATION AND HIV-1 SEROPREVALENCE IN A RURAL UGANDAN POPULATION
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DOI：
10.1097/00002030-199509050-00013
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发表时间：
1995-05-01
期刊：
影响因子：
3.8
通讯作者：
MULDER, DW
中科院分区：
文献类型：
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作者：
NUNN, AJ;WAGNER, HU;MULDER, DW
目的：研究乌干达农村人群居住变动与HIV - 1血清状况之间的关联。
设计：一项纵向队列研究。
方法：作为对乌干达西南部一个农村分区约10000人的人群队列年度监测的一部分，收集了所有成年人在3年期间居住变动及其与HIV - 1血清状况关联的信息。由一个医疗团队在家庭访问期间采集血清。在乌干达病毒研究所使用两种独立的酶联免疫吸附测定系统进行抗体检测，并在适当情况下进行蛋白质印迹法检测。
结果：在第四次调查中，总体年龄和性别标准化血清阳性率为7.9%；自第一次调查以来未变更住址的2129名成年人的阳性率为5.5%，在村内迁移的336人的阳性率为8.2%，迁移到邻村的128人的阳性率为12.4%，离开该地区的1130人的阳性率为11.5%，在过去3年中加入研究地区的541人的阳性率为16.3%（P远小于0.001，4个自由度）。我们还观察到在第一次调查时在当前房屋居住的年数与血清阳性率和随后的血清发病率之间呈反比关系。报告的终生性伴侣数量在那些变更居住的人中更高。
结论：在这个农村人群中，居住变动与HIV - 1感染风险增加密切相关，很可能是迁移者中更具风险性的性行为的结果。这些发现对艾滋病控制项目和干预研究的设计具有重要意义。
Objective: To study the association between change of residence and HIV-1 serostatus in a rural Ugandan population.Design: A longitudinal cohort study.Methods: As part of the annual surveillance of a population cohort of approximately 10 000 individuals in a rural subcounty of southwest Uganda, information has been collected for all adults on change of residence over a 3-year period and its association with HIV-1 serostatus. Sera were collected by a medical team during home visits. Antibody testing was performed at the Uganda Virus Research Institute using two independent enzyme immunoassay systems and Western blot when appropriate.Results: At the fourth survey-round, age and sex-standardized seroprevalence rates were 7.9% overall; the rate was 5.5% for 2129 adults who had not changed address since the first survey, 8.2% for 336 who moved within the village, 12.4% for 128 who moved to a neighbouring village, 11.5% for 1130 who had left the area and 16.3% for 541 who had joined the study area during the previous 3 years (P much less than 0.001, 4 degrees of freedom). We also observed an inverse relationship between years lived at the present house at the time of the first survey and both seroprevalence and subsequent seroincidence rates. The reported numbers of lifetime sexual partners were higher in those who changed residence.Conclusion: Change of residence is strongly associated with an increased risk of HIV-1 infection in this rural population and is likely to be the result of more risky sexual behaviour among those who move. These findings have important implications for the design of AIDS control programmes and intervention studies.