Piloting an integrated approach for estimation of environmental risk of Schistosoma haematobium infections in pre-school-aged children and their mothers at Barombi Kotto, Cameroon
Piloting an integrated approach for estimation of environmental risk of Schistosoma haematobium infections in pre-school-aged children and their mothers at Barombi Kotto, Cameroon
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DOI：
10.1016/j.actatropica.2020.105646
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发表时间：
2020-12-01
期刊：
影响因子：
2.7
通讯作者：
Stothard, J. R.
中科院分区：
文献类型：
--
作者：
Eyre, M. T.;Stanton, M. C.;Stothard, J. R.
在血吸虫病控制中，评估目前未接受治疗的人口群体（如学龄前儿童（PSAC）及其母亲）的环境风险非常重要。我们进行了一个试点微流行病学评估的火山口湖Barombi科托，喀麦隆与GPS跟踪和感染数据，从12 PSAC母亲对（n = 24）覆盖对环境采样，包括蜗牛，寄生虫和水的使用信息。几个高风险的位置或“热点”与水接触，增加中间蜗牛宿主密度和可检测的环境DNA（eDNA）被确定。PSAC和母亲对之间的暴露时间和空间相关，这表明可以同时使两组受益的干预措施可能是可行的。当试图在未来中断寄生虫传播时，蜗牛，寄生虫和水接触数据的叠加地图可以指导环境干预措施的精细尺度空间定位。
Within schistosomiasis control, assessing environmental risk of currently non-treated demographic groups e.g. pre-school-aged children (PSAC) and their mothers is important. We conducted a pilot micro-epidemiological assessment at the crater lake of Barombi Kotto, Cameroon with GPS tracking and infection data from 12 PSAC-mother pairs (n = 24) overlaid against environmental sampling inclusive of snail, parasite and water-use information. Several high-risk locations or 'hotspots' with elevated water contact, increased intermediate snail host densities and detectable schistosome environmental DNA (eDNA) were identified. Exposure between PSAC and mother pairs was temporally and spatially associated, suggesting interventions which can benefit both groups simultaneously might be feasible. When attempting to interrupt parasite transmission in future, overlaid maps of snail, parasite and water contact data can guide fine-scale spatial targeting of environmental interventions.