A receptor subtype involved in neuropeptide-Y-induced food intake
A receptor subtype involved in neuropeptide-Y-induced food intake
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DOI：
10.1038/382168a0
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发表时间：
1996-07-11
期刊：
影响因子：
64.8
通讯作者：
Weinshank, RL
中科院分区：
文献类型：
--
作者：
Gerald, C;Walker, MW;Weinshank, RL
神经肽Y （NPY）是一种强大的食物摄入兴奋剂，被认为可以激活下丘脑的“进食”受体，这与之前克隆的Y型受体不同(1)。该受体最初被认为可以解释对NPY和相关肽（包括NPY2-36）的喂养反应，这些肽与它们在Y1受体上的活性不同(2)。在这里，我们报道了一种来自大鼠下丘脑的新型y型受体的表达克隆，我们将其命名为Y5，互补DNA编码一个456个氨基酸的蛋白质，与已知y型受体的总体同源性低于35%，信使RNA主要存在于中枢神经系统。包括下丘脑室旁核。所选择的多肽通过Y5受体抑制腺苷酸环化酶和刺激大鼠食物摄入的程度吻合良好，我们的数据支持了Y5受体是假定的“喂养”受体的观点，并可能为肥胖和饮食失调的研究和治疗提供新的方法。
NEUROPEPTIDE Y (NPY) is a powerful stimulant of food intake and is proposed to activate a hypothalamic 'feeding' receptor distinct from previously cloned Y-type receptors(1). This receptor was first suggested to explain a feeding response to NPY and related peptides, including NPY2-36, that differed from their activities at the Y1 receptor(2), Here we report the expression cloning of a novel Y-type receptor from rat hypothalamus, which we name Y5, The complementary DNA encodes a 456-amino-acid protein with less than 35% overall identity to known Y-type receptors, The messenger RNA is found primarily in the central nervous system, including the paraventricular nucleus of the hypothalamus. The extent to which selected peptides can Inhibit adenylate cyclase through the Y5 receptor and stimulate food intake in rats correspond well, Our data support the idea that the Y5 receptor is the postulated 'feeding' receptor, and may provide a new method for the study and treatment of obesity and eating disorders.