Thermo-Responsive Hydrogels with Nanodomains: Rapid Shrinking of a Nanogel-Crosslinking Hydrogel of Poly(N-isopropyl acrylamide)
Thermo-Responsive Hydrogels with Nanodomains: Rapid Shrinking of a Nanogel-Crosslinking Hydrogel of Poly(N-isopropyl acrylamide)
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DOI：
10.1002/marc.200700864
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发表时间：
2008-04
影响因子：
4.6
通讯作者：
N. Morimoto;T. Ohki;K. Kurita;K. Akiyoshi
中科院分区：
文献类型：
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作者：
N. Morimoto;T. Ohki;K. Kurita;K. Akiyoshi
以胆固醇基和甲基丙烯酰基取代的普鲁兰(CHPMA)组成的自组装纳米凝胶为交联剂，制备了快速收缩的聚N-异丙基丙烯酰胺(PNIPAM)水凝胶。用CHPMA纳米凝胶(Rh=26.4 nm)作为亲水性纳米结构域的交联剂。纳米凝胶交联的PNIPAM水凝胶的透射电子显微镜图像显示出定义良好的纳米孔结构。纳米凝胶交联的PNIPAM水凝胶根据其结构表现出快速收缩的特征。收缩半衰期为≈2min，约为亚甲基(双丙烯酰胺)交联PNIPAM水凝胶的3400倍。
Rapidly shrinking poly(N-isopropyl acrylamide) (PNIPAM) hydrogels are prepared by crosslinking with self-assembled nanogels that consist of cholesteryl- and methacryloyl-substituted pullulan (CHPMA). The CHPMA nanogel (R h = 26.4 nm) was used as a crosslinker for a hydrophilic nanodomain. Transmission electron microscopy images of the nanogel-crosslinked PNIPAM hydrogel reveal a well-defined nanoporous structure. The nanogel-crosslinked PNIPAM hydrogel shows rapid shrinking based on its structure. The shrinking half-time was ≈2 min, which is about 3400 times faster than that of a PNIPAM hydrogel crosslinked by methylene(bisacrylamide).