Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial
Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial
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DOI：
10.1111/j.1742-481x.2011.00898.x
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发表时间：
2012-08-01
影响因子：
3.1
通讯作者：
Intanoo, Worawit
中科院分区：
文献类型：
--
作者：
Jenwitheesuk, Kamonwan;Surakunprapha, Palakorn;Intanoo, Worawit
据报道，使用有机硅衍生物和洋葱提取物可预防肥厚性疤痕。我们的经验表明，有机硅衍生物加洋葱提取物凝胶可预防正中胸骨切开术后的肥厚性疤痕。在一项随机、双盲、安慰剂对照研究中，60 名接受胸骨正中切口的患者被分为两组。所有患者均使用有机硅衍生物加洋葱提取物凝胶（Cybele (R) scagel）或安慰剂凝胶进行治疗，每天两次，总治疗期为 12 周。在每次就诊期间，患者对疼痛和瘙痒评分进行评分，外科医生使用温哥华疤痕量表观察疤痕特征。使用有机硅衍生物加洋葱提取物凝胶的患者的疼痛和瘙痒评分值低于另一组（P < 0.05）。两组之间色素沉着有显着差异（P < 0.05），治疗组血管分布、柔韧度、身高评分的降低并不优于未治疗组。没有任何患者报告不良事件。有机硅衍生物加洋葱提取物凝胶对于预防正中胸骨切开术后的肥厚性疤痕是安全有效的。
Use of silicone derivative and onion extract had been reported in the prevention of hypertrophic scarring. Our experience showed the preventive use of silicone derivative plus onion extract gel on hypertrophic scars after median sternotomy. In a randomized, double blinded, placebo-controlled study, 60 patients after median sternotomy incisions were separated into two groups. All patients were treated either with silicone derivative plus onion extract gel (Cybele (R) scagel) or placebo gel twice daily for a total treatment period of 12 weeks. During each visit, pain and itching scores were graded by the patients and scar characteristics were observed by surgeons using the Vancouver scar scale. Pain and itch score values from patients' who applied silicone derivative plus onion extract gel was less than another group (P < 0.05). Pigmentation was significantly different between two groups (P < 0.05) and the reduction of scores on vascularity, pliability, height in treated group was not superior to the untreated group. No adverse events were reported by any of the patients. A silicone derivative plus onion extract gel is safe and effective for the preventing the hypertrophic scarring after median sternotomy.