Evolutionary insights on the origin of human T-cell lymphoma/leukemia virus type I (HTLV-I) derived from sequence analysis of a new HTLV-I variant from Papua New Guinea.
Evolutionary insights on the origin of human T-cell lymphoma/leukemia virus type I (HTLV-I) derived from sequence analysis of a new HTLV-I variant from Papua New Guinea.
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对巴布亚新几内亚新 HTLV-I 变种的序列分析得出对人类 T 细胞淋巴瘤/白血病病毒 I 型 (HTLV-I) 起源的进化见解。
DOI：
10.1128/jvi.66.4.2556-2563.1992
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发表时间：
1992
影响因子：
5.4
通讯作者：
Poiesz,BJ
中科院分区：
文献类型：
--
作者：
Sherman,MP;Saksena,NK;Dube,DK;Yanagihara,R;Poiesz,BJ
最近的研究证实美拉尼西亚存在人类T细胞淋巴瘤/白血病病毒I型(HTLV-I)。现已从Hagahai的一名健康成员身上分离出HTLV-I毒株PNG-1，Hagahai是巴布亚新几内亚最近联系的一个偏远组织。为了进一步确定PNG-1的特征，我们采用了聚合酶链式反应扩增，并随后对扩增产物进行了克隆和测序。对该变异株Poll、env和px基因扩增区的序列分析表明，与原型HTLV-I有明显的异质性(约7%)。根据现有的序列数据，PNG-1不同于所有其他已知的HTLV-I毒株，并且在原型分离株之前与HTLV-I的共同祖先存在分歧。因此，数据还表明，HTLV-I起源于印度-马来地区，而不是非洲。
Recent studies have established the presence of human T-cell lymphoma/leukemia virus type I (HTLV-I) in Melanesia. An HTLV-I strain, PNG-1, has now been isolated from a healthy member of the Hagahai, a remote, recently contacted group in Papua New Guinea. To further characterize PNG-1, we employed polymerase chain reaction amplification with subsequent cloning and sequencing of amplified products. Sequence analyses of amplified regions of pol, env, and pX genes of this variant indicate marked heterogeneity (approximately 7%) from prototype HTLV-I. Based on available sequence data, PNG-1 is distinct from all other known HTLV-I strains and diverges from the common ancestor of HTLV-I prior to prototype isolates. The data also suggest, therefore, that HTLV-I originated in the Indo-Malay region rather than Africa.