Echinoderm immunity.
Echinoderm immunity.
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DOI：
10.1007/978-1-4419-8059-5_14
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发表时间：
2010
影响因子：
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通讯作者：
L. Smith;J. Ghosh;Katherine M. Buckley;Lori A. Clow;N. Dheilly;T. Haug;J. Henson;Chun Xing Li;C. Lun;A. Majeske;V. Matranga;S. Nair;J. Rast;D. Raftos;Mattias Roth;S. Sacchi;Catherine S. Schrankel;Klara Stensvåg
中科院分区：
文献类型：
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作者：
L. Smith;J. Ghosh;Katherine M. Buckley;Lori A. Clow;N. Dheilly;T. Haug;J. Henson;Chun Xing Li;C. Lun;A. Majeske;V. Matranga;S. Nair;J. Rast;D. Raftos;Mattias Roth;S. Sacchi;Catherine S. Schrankel;Klara Stensvåg
对紫海胆基因组中免疫基因的调查表明，免疫系统是复杂而精密的。由此推断，所有棘皮动物的免疫反应可能是相似的。免疫系统由几种类型的体腔细胞介导，这些体腔细胞也可用作环境压力的传感器。紫海胆基因组中有许多在免疫中发挥作用的大型基因家族，其中至少一个似乎采用了新的序列多样化方法。棘皮动物有更简单的补体系统、大量凝集素基因和大量抗菌肽。对体腔细胞表达的免疫基因和体腔液中的蛋白质进行分析可以提供有关海胆免疫功能的详细信息。棘皮动物在维持海洋生态系统稳定性方面的重要性以及由于疾病而消失的灾难性影响将需要生态学家和免疫学家之间的未来合作，致力于了解和保护海洋栖息地。
A survey for immune genes in the genome for the purple sea urchin has shown that the immune system is complex and sophisticated. By inference, immune responses of all echinoderms may be similar. The immune system is mediated by several types of coelomocytes that are also useful as sensors of environmental stresses. There are a number of large gene families in the purple sea urchin genome that function in immunity and of which at least one appears to employ novel approaches for sequence diversification. Echinoderms have a simpler complement system, a large set of lectin genes and a number of antimicrobial peptides. Profiling the immune genes expressed by coelomocytes and the proteins in the coelomic fluid provide detailed information about immune functions in the sea urchin. The importance of echinoderms in maintaining marine ecosystem stability and the disastrous effects of their removal due to disease will require future collaborations between ecologists and immunologists working towards understanding and preserving marine habitats.