Effects of buspirone on sleep and respiration.
Effects of buspirone on sleep and respiration.
复制标题
丁螺环酮对睡眠和呼吸的影响。
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
D. Rapoport
中科院分区：
文献类型：
--
作者：
W. Mendelson;Joseph V. Martin;D. Rapoport
Drugs used in the treatment of anxiety are frequently sedating and tend to be respiratory depressants. Buspirone, a nonbenzodiazepine anxiolytic agent, has little reported sedative effect. It has been shown to be a respiratory stimulant in an anesthetized, glomectomized cat model. In this study, we examined the effects of two intraperitoneal single doses (10 and 20 mg/kg) of buspirone on sleep and respiration in unanesthetized, intact, freely moving rats. Buspirone increased sleep latency (p less than 0.0001) and decreased total sleep (p less than 0.02) through reductions in both non-REM and REM sleep. Respiratory rate (p less than 0.0003) and ventilation (p less than 0.004) were significantly increased for 4 h after drug injection. The effects on respiration were independent of those on sleep; stimulation was evident in both waking and non-REM sleep. This study suggests that buspirone, in addition to being free of sedating and respiratory depressant side effects when prescribed for anxiety in humans, may be a respiratory stimulant whose effects persist in sleep.
衰老和睡眠呼吸暂停：苯二氮卓类、乙酰唑胺、酒精和睡眠剥夺对健康老年人群的作用。
DOI：
10.1093/geronj/39.6.655
发表时间：
1984
期刊：
Journal of gerontology
影响因子：
--
作者：
Guilleminault,C;Silvestri,R;Mondini,S;Coburn,S
通讯作者：
Coburn,S