Animal Mitochondria: Evolution, Function, and Disease
Animal Mitochondria: Evolution, Function, and Disease
复制标题
动物线粒体：进化、功能和疾病
DOI：
10.2174/15665240113136660081
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Liu, Y.
中科院分区：
文献类型：
--
作者：
Tao, M.;You, C. -P.;Liu, Y.
线粒体是亚细胞器，通过氧化磷酸化（OXPHOS）过程负责产生大部分细胞能量，几乎存在于所有真核细胞中。线粒体拥有独特的遗传系统，即线粒体DNA（mtDNA），它是一个小型、可自我复制且多样的基因组。在过去30年中，线粒体DNA对分子生态学和系统地理学做出了重大贡献。线粒体也代表了一种独特的线粒体 - 细胞核基因组协作系统。此外，线粒体功能障碍可能是致命的。在本文中，我们综述了线粒体的几个方面，包括线粒体的进化和起源、能量供应以及线粒体在细胞凋亡中的核心作用，还有线粒体功能障碍。研究表明线粒体在生命的许多方面都起着至关重要的作用。
Mitochondria are sub-cellular organelles responsible for producing the majority of cellular energy through the process of oxidative phosphorylation (OXPHOS), and are found in nearly all eukaryotic cells. Mitochondria have a unique genetic system, mitochondrial DNA (mtDNA), which is a small, self-replicating and diverse genome. In the past 30 years, mtDNA has made significant contribution to molecular ecology and phylogeography. Mitochondria also represent a unique system of mitochondrial-nuclear genomic cooperation. Additionally, mitochondrial dysfunction can be fatal. In this paper, we review several aspects of mitochondria, including evolution and the origin of mitochondria, energy supply and the central role of mitochondria in apoptosis, and mitochondrial dysfunction. It is shown that mitochondria play a critical role in many aspects of life.