Phenotypic polarization of macrophages in atherosclerosis.
Phenotypic polarization of macrophages in atherosclerosis.
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DOI：
10.1161/atvbaha.112.300173
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Schulman IG
中科院分区：
文献类型：
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作者：
Leitinger N;Schulman IG
巨噬细胞协调发炎组织中的炎症反应，最近的研究表明这些细胞可以根据微环境的变化相应地改变其表型和功能。心血管疾病模型的初步工作使用免疫标记物来表征动脉粥样硬化斑块中存在的巨噬细胞表型，这些研究最近通过使用对动脉粥样硬化和代谢疾病更特异性的标记物进行了扩展。这些研究共同得出了关于巨噬细胞在动脉粥样硬化发展中的功能的新观点，表明巨噬细胞具有动态可塑性。了解这种可塑性和随之而来的巨噬细胞异质性可能会导致药物干预的新策略来对抗代谢疾病中的慢性炎症。最重要的是，揭示个体巨噬细胞表型的功能特征将有助于更好地了解它们对病变发展和斑块稳定性的贡献。
Macrophages orchestrate the inflammatory response in inflamed tissues and recent work indicates that these cells can alter their phenotypes and functions accordingly in response to changes in the microenvironment. Initial work in models of cardiovascular disease used immunological markers to characterize macrophage phenotypes present in atherosclerotic plaque and these studies have lately been extended through the use of markers that are more specific for atherosclerosis and metabolic disease. Together these studies have led to a novel view of the function of macrophages in the development of atherosclerosis that suggests a dynamic plasticity. Understanding this plasticity and the ensuing macrophage heterogeneity could lead to novel strategies of pharmacological intervention to combat chronic inflammation in metabolic diseases. Most importantly, revealing the functional characteristics of individual macrophage phenotypes will lead to a better understanding of their contribution to lesion development and plaque stability.