Characteristics and contributions of hyperandrogenism to insulin resistance and other metabolic profiles in polycystic ovary syndrome
Characteristics and contributions of hyperandrogenism to insulin resistance and other metabolic profiles in polycystic ovary syndrome
复制标题
高雄激素血症的特征以及对多囊卵巢综合征胰岛素抵抗和其他代谢特征的影响
DOI：
10.1111/aogs.12612
复制
发表时间：
2015-05-01
影响因子：
4.3
通讯作者：
Liu, Wei
中科院分区：
文献类型：
--
作者：
Huang, Rong;Zheng, Jun;Liu, Wei
目的探讨中国汉族多囊卵巢综合征患者的不同特征，并分析高雄激素血症在胰岛素抵抗及其他代谢方面的意义。设计一项横断面研究。地点医科大学附属医院。人群共229例多囊卵巢综合征患者，年龄18- 45岁。方法按鹿特丹标准诊断的多囊卵巢综合征患者，根据游离雄激素指数水平的四分位数区间将患者分为四组，主要观察指标采用单因素方差分析进行组间比较。结果在4种表型中，表型1（高雄激素血症、少排卵/无排卵和多囊卵巢）的女性总睾酮、游离雄激素指数、雄烯二酮、低密度脂蛋白水平较高，胰岛素敏感性检查指数较低（P
ObjectiveTo investigate the different characteristics in Chinese Han women with polycystic ovary syndrome, and to analyze the significance of hyperandrogenism in insulin resistance and other metabolic profiles.DesignA cross-sectional study.SettingMedical university hospital.PopulationA total of 229 women with polycystic ovary syndrome aged 18-45years.MethodsWomen with polycystic ovary syndrome, diagnosed by Rotterdam criteria, were divided into four groups according to the quartile intervals of free androgen index levels.Main outcome measuresComparisons between groups were performed using one-way analysis of variance. Stepwise logistic regression analysis was performed to investigate the association between homeostasis model assessment-insulin resistance and independent variables.ResultsWithin the four phenotypes, women with phenotype 1 (hyperandrogenism, oligo/anovulation, and polycystic ovaries) exhibited higher total testosterone, free androgen index, androstenedione, low-density lipoprotein, and lower quantitative insulin sensitivity check index (p