RESPONSES OF HIPPOCAMPAL-FORMATION NEURONS IN THE MONKEY RELATED TO DELAYED SPATIAL RESPONSE AND OBJECT PLACE MEMORY TASKS
RESPONSES OF HIPPOCAMPAL-FORMATION NEURONS IN THE MONKEY RELATED TO DELAYED SPATIAL RESPONSE AND OBJECT PLACE MEMORY TASKS
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DOI：
10.1016/s0166-4328(89)80118-4
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发表时间：
1989-07-01
影响因子：
2.7
通讯作者：
ROLLS, ET
中科院分区：
文献类型：
--
作者：
CAHUSAC, PMB;MIYASHITA, Y;ROLLS, ET
在灵长类动物包括人类中，对特定视觉刺激在环境中的位置的记忆是海马损伤相对特异性损害的记忆类型之一，为了研究海马可能执行的与这种记忆类型相关的加工，记录了猴子在执行物体-位置记忆任务时海马神经元的活动。在这个实验中，猴子在视频屏幕上的一个位置被显示刺激，有2秒的延迟，然后在相同或不同的位置显示相同或不同的刺激。猴子记住了样本和它的位置，如果两者都与延迟刺激相匹配，他就舔得到果汁。在这项任务中分析的600个神经元中，3.8%对不同的空间位置有不同的反应，其中一些在样品呈现期间，一些在延迟期，一些在匹配期。因此，一些海马神经元对空间中不同位置的刺激有不同的反应，而一些海马神经元对猴子记忆空间中不同位置的刺激有不同的反应。此外，一些神经元对物体和地点信息的组合做出反应，因为它们只对特定地点的新物体做出反应。这些神经元反应并不是由于猴子做出或准备的任何反应，因为在显示匹配刺激之前，关于需要哪种行为反应的信息是不可用的。这是第一次证明灵长类动物的海马神经元具有与刺激的空间位置相关的活动。这些神经元的活动也在延迟空间反应任务中测量，其中猴子在一个位置显示刺激，并且在2秒延迟后，当显示两个相同的刺激时，必须达到触摸刺激，该刺激位于先前看到的位置。结果发现，在物体位置记忆任务中有反应的神经元在延迟反应任务中没有反应。相反，不同的神经元群体（占总数的5.7%）在延迟空间反应任务中做出反应，在样本，延迟或匹配期间具有不同的左右反应。因此，这群海马神经元具有与空间反应的准备或启动相关的活动，一旦看到样本刺激，就可以在延迟反应任务中编码。结论：（1）灵长类动物海马中存在与刺激的空间位置或刺激空间位置记忆有关的神经元活动（如物体-位置记忆任务）;此外，（2）这些神经元中的一些对关于物体和物体被看到的位置的信息的组合做出反应。我们还得出结论：（3）海马中还有其他神经元的活动与刺激或刺激的记忆无关，而是与猴子准备和记忆的空间反应有关（如延迟空间反应任务所示）。
The memory for where in the environment a particular visual stimulus has been seen is one of the types of memory relatively specifically impaired by hippocampal damage in primates including man. In order the investigate what processing might be performed by the hippocampus related to this type of memory, the activity of hippocampal neurons was recorded while monkeys performed and object-place memory task. In this, the monkey was shown stimulus in one position on a video screen, there was a delay of 2s, and then the same or a different stimulus was shown in the same or in a different position. The monkey remembered the sample and its position, and if both matched the delayed stimulus, he licked to obtained fruit juice. Of the 600 neurons analysed in this task, 3.8% responded differently for the different spatial positions, with some of these responding differentally during the sample presentation, some in the delay period, and some in the matched period. Thus some hippocampal neurons respond differently for stimuli shown in different positions in space, and some respond differently when the monkey is remembering different positions in space. In addition some of the neurons responded to a combination of object and place information, in that they responded only to a novel object in a particular place. These neurnoal responses were not due to any response being made or prepared by the monkey, for information about which behavioral response was required was not available until the match stimulus was shown. This is the first demonstration that some hippocampal neurons in the primate have activity related to the spatial position of stimuli. The activity of these neurons was also measured in a delayed spatial response task, in which the monkey was shown a stimulus in one position, and, after a 2 s delay when two identical stimuli were shown, had to reach to touch the stimulus which was in the position in which it had previously been seen. It was found that the majority of the neurons which responded in the object-place memory task did not respond in the delayed response task. Instead, a different population of neurons (5.7% of the total) responded in the delayed spatial response task, with differential left-right responses in the sample, delay, or match periods. Thus this population of hippocampal neurons had activity which was related to the preparation for or initiation of a spatial response, which can be encoded in the delayed response task as soon as the sample stimulus is seen. It is concluded (1) that there are some neurons in the primate hippocampus with activity which is related to the spatial position of stimuli or the memory of the spatial position of stimuli (as shown in the object-place memory task). Further, (2) some of these neurons responded to a combination of information about the object and the position in which it was seen. It is also concluded (3) there are other neurons in the hippocampus with activity which is related not to the stimulus or the memory of the stimulus, but instead to the spatial response which the monkey is preparing and remembering (as shown in the delayed spatial response task).