Acceptability of Vaginal Film, Soft-Gel Capsule, and Tablet as Potential Microbicide Delivery Methods Among African Women
Acceptability of Vaginal Film, Soft-Gel Capsule, and Tablet as Potential Microbicide Delivery Methods Among African Women
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DOI：
10.1089/jwh.2010.2476
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发表时间：
2011-08-01
影响因子：
3.5
通讯作者：
Norick, Pamela M.
中科院分区：
文献类型：
--
作者：
Nel, Annalene M.;Mitchnick, Lynne B.;Norick, Pamela M.
背景：阴道杀菌剂正在开发中，以防止通过性交将艾滋病毒传播给女性。杀微生物剂给药方法在目标人群中的可接受性对产品粘附性和产品有效性很重要。预计将需要多种给药方式来满足未来杀微生物剂使用者的个人偏好。方法：在布基纳法索、坦桑尼亚和赞比亚，共有526名18-30岁的性活跃女性参与了一项消费者产品偏好研究。给予同意的筛查妇女被指示每天使用三种产品(阴道片剂、薄膜和软凝胶胶囊的安慰剂制剂)中的每一种，连续7天，总共21天。结果：超过80%的女性表示喜欢使用每种剂型，超过85%的女性表示肯定会使用。选择薄膜和软凝胶胶囊作为首选剂型的频率明显高于片剂(分别为39%和37%对25%)，主要是因为更快的溶解时间和更容易插入。布基纳法索和坦桑尼亚的女性更喜欢软凝胶胶囊(42%-46%)，而赞比亚女性更喜欢这种电影(51%)。年龄、社会经济状况和婚姻状况对产品偏好没有显著影响。结论：三种剂型均可接受。首选的剂型因国家而异。这些数据表明，多种剂型的杀微生物剂的可用性可能会增加可接受性、依从性，从而提高有效性。
Background: Vaginal microbicides are in development for the prevention of HIV transmission to women via sexual intercourse. Acceptability of the microbicide delivery method in the targeted population is important to product adherence and, therefore, product effectiveness. It is anticipated that multiple delivery methods will be required to satisfy personal preferences among future microbicide users.Methods: A total of 526 sexually active women aged 18-30 years participated in a consumer product preference study in Burkina Faso, Tanzania, and Zambia. Screened women who had given consent were instructed to use each of the three products (placebo formulations of a vaginal tablet, film, and soft-gel capsule) once daily for 7 consecutive days for a total of 21 days. Women were interviewed about their impressions of the product at the completion of each 7-day trial period.Results: Over 80% of women reported they liked using each dosage form, and over 85% said they would definitely use it. The film and soft-gel capsule were chosen significantly more often than the tablet as the preferred dosage form (39% and 37% vs. 25%, respectively) mainly because of faster dissolving time and easier insertion. Women in Burkina Faso and Tanzania preferred the soft-gel capsule (42%-46%), whereas Zambian women preferred the film (51%). Age, socioeconomic status, and marital status did not significantly affect product preference.Conclusions: All three dosage forms were acceptable to the women surveyed. Preferred dosage forms varied by country. These data suggest that the availability of microbicides in multiple dosage forms may increase acceptability, adherence, and, therefore, effectiveness.