Current evidence on the relationship between three polymorphisms in the XRCC7 gene and cancer risk
Current evidence on the relationship between three polymorphisms in the XRCC7 gene and cancer risk
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DOI：
10.1007/s11033-012-2018-9
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发表时间：
2012
影响因子：
2.8
通讯作者：
Jian Zhang;Xiang-hua Wu;Yunhui Gan
中科院分区：
文献类型：
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作者：
Jian Zhang;Xiang-hua Wu;Yunhui Gan
注意到XRCC 7多态性与癌症关联的不一致性。本研究选取3个常见的XRCC 7基因多态性rs7003908（T>G）、rs7830743（A>G）和rs 10109984（T>C），通过对已发表的病例对照研究的Meta分析，探讨其与癌症发生风险的关系。结果显示，当所有研究合并到荟萃分析中时，在任何模型中均未发现rs7003908、rs7830743和rs 10109984与癌症风险的显著相关性。但是，当按癌症类型分层时，仅在前列腺癌中发现rs7003908的统计学显著升高的癌症风险。（GG vs. TT：OR = 1.845，95%CI = 1.178-2.888;显性模型：OR = 1.423，95%CI = 1.050-1.929;隐性模型：OR = 1.677，95%CI = 1.133-2.482）。在按种族或研究设计进行的亚组分析中，未发现所有三种多态性的风险显著增加。本荟萃分析提示XRCC 7 rs7003908多态性可能与前列腺癌的易感性有关，建议纳入未来的大样本研究和功能检测中。
Inconsistency of the association of polymorphisms ofXRCC7with cancer is noted. Three commonly studiedXRCC7polymorphisms including rs7003908 (T>G), rs7830743 (A>G), and rs10109984 (T>C) were selected to explore their association with risk of development of cancer by meta-analysis of published case–control studies. The results showed that no significant associations with cancer risk were found in any model in terms of rs7003908, rs7830743 and rs10109984 when all studies were pooled into the meta-analysis. But when stratified by cancer type, statistically significantly elevated cancer risk was only found in prostate cancer for rs7003908 (GG vs. TT: OR = 1.845, 95 % CI = 1.178–2.888; dominant model: OR = 1.423, 95 % CI = 1.050–1.929; recessive model: OR = 1.677, 95 % CI = 1.133–2.482). In the subgroup analysis by ethnicity or study design, no significantly increased risks were found for all three polymorphisms. This meta-analysis suggests thatXRCC7rs7003908 polymorphism may contribute to cancer susceptibility for prostate cancer, which is recommended to be included in future large-sample studies and functional assays.