The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders.
The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders.
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DOI：
10.2174/1871527315666160413120845
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kosaka H
中科院分区：
文献类型：
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作者：
Okamoto Y;Ishitobi M;Wada Y;Kosaka H
有人建议使用催产素来治疗自闭症谱系障碍 (ASD) 的核心症状，包括社交沟通缺陷。先前的临床试验已经研究了催产素鼻内单剂量和长期给药对自闭症谱系障碍患者的有效性和安全性。所有研究均表明单剂量和长期给药耐受性良好，且尚未报告严重不良事件。然而，长期施用催产素的疗效存在争议。一些研究报告称，长期施用催产素可以显着改善自闭症谱系障碍的核心症状，而其他研究则表明没有这种改善。为了阐明影响催产素给药效果的因素，有必要检查给药方案（例如剂量、每天的频率）和参与者特征（例如年龄、性别、智力）的影响。除了对特定给药方法的功效存在疑问外，鼻内催产素对中枢神经系统的作用机制也存在疑问。检查社会行为的神经基础变化以及血液或脑脊液中催产素水平的同步变化对于阐明鼻内催产素给药的药代动力学非常重要，这对于为自闭症谱系障碍患者建立最佳催产素治疗至关重要。
Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individuals with ASD. All studies suggest that single-dose and long-term administration are well tolerated, and no severe adverse events have been reported. However, the efficacy of long-term oxytocin administration is controversial. Some studies have reported significant improvement of the core symptoms of ASD by long-term oxytocin administration, while other studies showed no such improvement. To elucidate the factors influencing the efficacy of oxytocin administration, it is necessary to examine the effects of administration schedules (e.g., dosage amount, frequency per day) and participant characteristics (e.g., age, sex, intellectual ability). In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system. Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal oxytocin administration, which could be essential for establishing optimal oxytocin treatments for individuals with ASD.