Are Convulsant Gases Also Anesthetics?
Are Convulsant Gases Also Anesthetics?
复制标题
惊厥气体也是麻醉剂吗？
DOI：
10.1097/00000542-198009001-00047
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发表时间：
1980
影响因子：
5.7
通讯作者：
L. Speers
中科院分区：
文献类型：
--
作者：
D. Koblin;E. Eger;B. Johnson;P. Collins;R. Terrell;L. Speers
本研究探讨了惊厥气体氟甲基是否偏离麻醉效力与脂溶性之间的相关性。在0.122 ± 0.006%大气压下，氟乙基（CF 3CH 2 OCH 2CF 3）在50%的小鼠中产生惊厥。小鼠暴露于氟草醚后常出现反复惊厥，以0.24%大气压时惊厥次数最多。浓度大于0.6%大气压后，立即产生惊厥，但很少在以后的时间。当浓度为1.22 ± 0.19%大气压时，测得翻正反射消失的ED_（50）值。发现在37 ℃下氟代甲基的油/气分配系数为46.9。右反射ED 50和油/气分配系数的乘积（0.0122 atm × 46.9 = 0.57 atm）与小鼠中常规麻醉剂的结果相似。因此，氟乙基不会偏离麻醉效力和脂溶性的相关性。0.3%~ 0.8%atm的氟哌酸使犬异氟醚MAC增加，3%~ 4%atm的氟哌酸使其降低，低浓度氟哌酸使异氟醚需要量增加，提示可能引起惊厥的麻醉药可部分拮抗其自身的麻醉作用。在较高浓度的氟乙基下，犬中异氟烷MAC的降低也表明该化合物具有麻醉作用。氟乙基的结构异构体异吲哚酮[（CF 3）2CHOCH 3]仅具有麻醉作用，不具有惊厥特性。对狗的MAC为4.60 ± 0.45%atm，对小鼠的右反射ED_（50）为2.65 ± 0.13%atm。犬异吲哚酮MAC与油/气分配系数（27.0）的乘积为1.24 atm，小鼠异吲哚酮右反射ED_（50）与油/气分配系数的乘积为0.72 atm。这些值与犬和小鼠中常规麻醉剂的结果接近;因此，异吲哚酮也未偏离麻醉效价与脂质溶解度之间的相关性。
This study investigated whether the convulsasnt gas flurothyl deviates from the correlation between anesthetic potency and lipid solubility. Flurothyl (CF3CH2OCH2CF3) produced convulsions in 50% of mice at 0.122 ± 0.006% atm. Mice often convulsed repeatedly after exposure to flurothyl, the maximum number of convulsions occurring when the concentration was 0.24% atm. Concentrations greater than 0.6% atm produced convulsions immediately after addition of flurothyl, but rarely at later times. An ED50 value for loss of the righting reflex was obtained when the concentration was 1.22 ± 0.19% atm. The oil/gas partition coefficient was found to be 46.9 for flurothyl at 37 C. The product of righting-reflex ED50 and oil/gas partition coefficient (0.0122 atm × 46.9 = 0.57 atm) is similar to that found for conventional anesthetics in mice. Therefore, flurothyl does not deviate from the correlation of anesthetic potency and lipid solubility. It was also found that 0.3 to 0,8% atm flurothyl increased isoflurane MAC in dogs, but that 3 to 4% atm flurothyl decreased it. The increase of isoflurane requirement at lower concentrations of flurothyl suggests that anesthetics with a potential to cause convulsions may partly antagonize their own anesthetic effect. The decrease in isoflurane MAC in dogs at higher concentrations of flurothyl also implies that this compound has an anesthetic effect. A structural isomer of flurothyl, iso-Indoklon [(CF3)2CHOCH3], was only anesthetic and did not have convulsant properties. Its MAC in dogs was 4.60 ± 0.45% atm, and its righting-reflex ED50 in mice was 2.65 ± 0.13% atm. The product of iso-lndoklon MAC in dogs and its oil/gas partition coefficient (27.0) was 1.24 atm, and the product of iso-Indoklon righting-reflex ED50 in mice and oil/gas partition coefficient was 0.72 atm. These values are close to those found for conventional anesthetic agents in dogs and mice; thus iso-Indoklon also does not deviate from the correlation between anesthetic potency and lipid solubilities.