Myeloid-derived suppressor cells exacerbate Sjogren's syndrome by inhibiting Th2 immune responses
Myeloid-derived suppressor cells exacerbate Sjogren's syndrome by inhibiting Th2 immune responses
复制标题
骨髓源性抑制细胞通过抑制 Th2 免疫反应加剧干燥综合征
DOI：
10.1016/j.molimm.2018.07.016
复制
发表时间：
2018-09-01
影响因子：
3.6
通讯作者：
Hou, Yayi
中科院分区：
文献类型：
--
作者：
Qi, Jingjing;Li, Dan;Hou, Yayi
髓系来源的抑制细胞(MDSCs)基于其强大的免疫抑制活性，可以调节免疫反应的各个方面。研究表明，MDSCs参与了许多自身免疫性疾病。然而，MDSCs在干燥综合征(SS)中的作用尚不清楚。在这项研究中，我们测定了非肥胖糖尿病(NOD)小鼠和SS患者中MDSCs的频率和功能。用MDSCs过继转移NOD小鼠或用抗Gr1抗体治疗。结果表明，随着NOD小鼠SS样综合征的发展，外周血中MDSCs的数量明显增加，SS患者的MDSCs比例明显高于正常对照组。在NOD小鼠体内移植MDSCs后，类SS综合征加重。NOD小鼠骨髓间充质干细胞的缺失可缓解SS样综合征。机制上，MDSCs下调NOD小鼠和SS患者Th2细胞的百分比。综上所述，我们的研究结果表明，MDSCs通过抑制Th2细胞加重了干燥综合征。
Myeloid-derived suppressor cells (MDSCs) can regulate various aspects of immune responses based on their potent immune-suppressive activity. Studies reported that MDSCs participated in many autoimmune diseases. However, the role of MDSCs in Sjogren's syndrome (SS) is unknown. In this study, we determined the frequencies and function of MDSCs in non-obese diabetic (NOD) mice and SS patients. The NOD mice were adoptively transferred with MDSCs or treated with anti-Gr1 antibody. Results showed that peripheral MDSCs increased significantly with the development of SS-like syndrome in NOD mice and the percentage of MDSCs was higher in SS patients than healthy controls. The SS-like syndrome aggravated after transfer of MDSCs in NOD mice. The deletion of MDSCs in NOD mice alleviated SS-like syndrome. Mechanistically, MDSCs down-regulated the percentages of Th2 cells in NOD mice and SS patients. In summary, our findings suggested that MDSCs exacerbated Sjogren's syndrome by inhibiting Th2 cells.