One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the Sonogashira coupling reaction
One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the Sonogashira coupling reaction
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DOI：
10.1021/ol026266n
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发表时间：
2002-09-19
期刊：
影响因子：
5.2
通讯作者：
Grieco, PA
中科院分区：
文献类型：
--
作者：
Mio, MJ;Kopel, LC;Grieco, PA
Sonogoshira偶联反应采用脒碱和亚化学计量量的水的修改通过三甲基甲硅烷基乙炔添加的中间体的原位脱保护在一锅中产生对称和不对称的双芳基乙炔。
A modification of the Sonogoshira coupling reaction employing an amidine base and a substoichiometric amount of water generates symmetrical and unsymmetrical bisarylethynylenes in one pot through in situ deprotection of trimethylsilylethynylene-added intermediates.