Synchrony and desynchrony in circadian clocks: impacts on learning and memory.
Synchrony and desynchrony in circadian clocks: impacts on learning and memory.
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DOI：
10.1101/lm.038877.115
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Lyons LC
中科院分区：
文献类型：
--
作者：
Krishnan HC;Lyons LC
生物钟在环境变化的条件下进化，主要是交替明暗周期，使生物体能够预测日常环境事件并协调代谢、生理和行为活动。然而，现代生活方式和技术进步增加了在与自然昼夜活动节律不符的阶段工作的人的比例。内源性昼夜节律振荡器调节警觉性、学习能力的获得、记忆形成和记忆的回忆，从无脊椎动物到人类的各个门中观察到的昼夜节律调节记忆的例子。当与自然昼夜节律不同步时，认知表现和记忆力会显着下降。昼夜节律紊乱可能导致记忆形成受损和其他认知缺陷的表现。这篇综述探讨了生物钟调节认知的相互作用类型，强调了识别昼夜节律系统与记忆形成过程之间机械相互作用的最新进展，并概述了用于补救昼夜节律扰动和加强昼夜节律适应的方法。
Circadian clocks evolved under conditions of environmental variation, primarily alternating light dark cycles, to enable organisms to anticipate daily environmental events and coordinate metabolic, physiological, and behavioral activities. However, modern lifestyle and advances in technology have increased the percentage of individuals working in phases misaligned with natural circadian activity rhythms. Endogenous circadian oscillators modulate alertness, the acquisition of learning, memory formation, and the recall of memory with examples of circadian modulation of memory observed across phyla from invertebrates to humans. Cognitive performance and memory are significantly diminished when occurring out of phase with natural circadian rhythms. Disruptions in circadian regulation can lead to impairment in the formation of memories and manifestation of other cognitive deficits. This review explores the types of interactions through which the circadian clock modulates cognition, highlights recent progress in identifying mechanistic interactions between the circadian system and the processes involved in memory formation, and outlines methods used to remediate circadian perturbations and reinforce circadian adaptation.