Bone marrow-derived hepatocytes : rare but promising.
Bone marrow-derived hepatocytes : rare but promising.
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DOI：
10.1016/s0002-9440(10)64188-0
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发表时间：
2002-08
期刊：
影响因子：
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通讯作者：
C. Mitchell;N. Fausto
中科院分区：
文献类型：
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作者：
C. Mitchell;N. Fausto
In the past 3 years, several reports have demonstrated the capacity of bone marrow stem cells to transdifferentiate into hepatocytes. 1–5 These findings created enormous interest because they uncovered a new property of bone marrow stem cells and opened the possibility that these cells could be used in the treatment of liver injury and acute or chronic liver failure. Even though it is now widely accepted that the transdifferentiation phenomenon is real, many questions still remain. There has been a great divergence among the reports concerning the efficiency of hepatocyte replacement after bone marrow transplantation. Moreover, it was uncertain whether the transdifferentiation events were dependent on liver damage. In this issue of The American Journal of Pathology, Wang et al6 address these questions and advance our understanding of the intriguing and fascinating phenomenon of the generation of hepatocytes by bone marrow stem cells. They conclude that hepatocyte replacement by bone marrow cells is a slow and rare event that can occur independently of liver injury. The first demonstration of transdifferentiation of bone marrow cells into liver cells was obtained in 1999 by Petersen et al. 3 In this study, irradiated female rats received bone marrow cells from congenic male rats and their livers were subsequently injured by a treatment of carbon tetrachloride and 2-acetyl-aminofluorene, which prevented hepatocyte division and stimulated oval cell proliferation. The results obtained by Petersen et al3 demonstrated that oval cells arose from hematopoietic precursors and gave rise to Y-chromosome-positive hepatocytes.
