Effects of pancreatic polypeptide, caerulein, and bombesin on satiety in obese mice.
Effects of pancreatic polypeptide, caerulein, and bombesin on satiety in obese mice.
复制标题
胰多肽、雨蛙素和铃蟾肽对肥胖小鼠饱腹感的影响。
DOI：
10.1152/ajpgi.1985.248.3.g277
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Garcia,R
中科院分区：
文献类型：
--
作者：
Taylor,IL;Garcia,R
先天性肥胖的老鼠是贪食的，这表明它们的肥胖是继发于正常饱腹感机制的缺陷。本研究比较了雨蛙肽、蛙皮素和胰多肽（3、9和27 nmol/kg三种等摩尔剂量）对10对瘦小鼠和肥胖小鼠摄食量的影响。腹腔注射生理盐水后，肥胖小鼠比同窝出生的瘦小鼠多吃240%的液体食物（Magnacal）（P <0.01）。所有三种剂量的雨蛙肽都显著抑制了肥胖和瘦小鼠的食物摄入。尽管最高剂量的蛙皮素显著降低了肥胖和瘦小鼠的食物摄入量，但最低剂量仅对肥胖小鼠有效。相比之下，这些剂量的胰多肽对瘦小鼠或肥胖小鼠的食物摄入量都没有显著影响。需要200 nmol/kg剂量的牛胰多肽才能显著降低瘦小鼠和肥胖小鼠的摄食量。这项研究表明，肥胖小鼠对饱腹感信号做出反应，甚至可能比它们的瘦同胞对某些信使更敏感。此外，先前描述的通过剂量约为2.5和25 nmol X kg-1 X day-1的胰多肽逆转该肥胖综合征不太可能是由于该肽对食物摄入的影响。
Congenitally obese mice are hyperphagic, suggesting that their obesity is secondary to defects in normal satiety mechanisms. The present study compares the effects of caerulein, bombesin, and pancreatic polypeptide (three equimolar doses each of 3, 9, and 27 nmol/kg) on food intake in 10 pairs of lean and obese mice. After the intraperitoneal injection of saline, obese mice eat 240% more of a liquid meal (Magnacal) than their lean littermates (P less than 0.01). All three doses of caerulein significantly inhibited food intake in both obese and lean mice. Although the highest dose of bombesin significantly decreased food intake in both obese and lean mice, the lowest dose was only effective in obese mice. In contrast, none of these doses of pancreatic polypeptide had a significant effect on food intake in either lean or obese mice. A dose of bovine pancreatic polypeptide of 200 nmol/kg was required to significantly reduce food intake in lean and obese mice. This study demonstrates that obese mice respond to satiety signals and may even be more sensitive than their lean littermates to some messengers. In addition, the previously described reversal of this obesity syndrome by pancreatic polypeptide in doses of approximately 2.5 and 25 nmol X kg-1 X day-1 is unlikely to be due to effects of this peptide on food intake.