Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis
Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis
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DOI：
10.1016/s1473-3099(20)30482-5
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发表时间：
2020-09-01
影响因子：
56.3
通讯作者：
Tamura, Kaku
中科院分区：
文献类型：
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作者：
Tabata, Sakiko;Imai, Kazuo;Tamura, Kaku
背景持续的COVID-19大流行是一个全球性威胁。识别症状发作和疾病进展的标志物是一个紧迫的问题。我们描述了钻石公主号邮轮上被确诊为无症状严重急性呼吸综合征冠状病毒2型感染者的临床特征（SARS-CoV-2）感染或轻度或重度COVID-19，在自卫队中央医院住院时（日本东京）和观察结束时。方法本回顾性研究，单中心研究包括实验室检测到SARS-CoV-2感染的参与者，他们于2020年2月11日至2月25日入住自卫队中央医院。分析临床记录、实验室数据和放射学结果。临床结局随访至出院或2020年2月26日，以先到者为准。我们将无症状感染定义为无临床体征和症状史的SARS-CoV-2感染，将重度COVID-19定义为肺炎的临床症状（呼吸困难、呼吸急促、外周毛细血管血氧饱和度
Background The ongoing COVID-19 pandemic is a global threat. Identification of markers for symptom onset and disease progression is a pressing issue. We described the clinical features of people infected on board the Diamond Princess cruise ship who were diagnosed with asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or mild or severe COVID-19, on admission to the Self-Defense Forces Central Hospital (Tokyo, Japan) and at the end of observation.Methods This retrospective, single-centre study included participants with laboratory-detected SARS-CoV-2 infection who were admitted to the Self-Defense Forces Central Hospital from Feb 11 to Feb 25, 2020. Clinical records, laboratory data, and radiological findings were analysed. Clinical outcomes were followed up until discharge or Feb 26, 2020, whichever came first. We defined asymptomatic infection as SARS-CoV-2 infection with no history of clinical signs and symptoms, severe COVID-19 as clinical symptoms of pneumonia (dyspnoea, tachypnoea, peripheral capillary oxygen saturation