Prevention of influenza-related illness in young infants by maternal vaccination during pregnancy.
Prevention of influenza-related illness in young infants by maternal vaccination during pregnancy.
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DOI：
10.12688/f1000research.12473.1
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Madhi SA
中科院分区：
文献类型：
--
作者：
Nunes MC;Madhi SA
流感病毒每年都在传播，并引起全球流行病。流感感染影响所有年龄组，可引起轻微至严重的疾病，幼儿特别容易患严重疾病。预防流感最有效的措施是接种疫苗；然而，没有疫苗被许可用于6个月以下的婴儿。因此，在这一高危年龄组急需采取其他预防策略。怀孕期间接种流感疫苗可保护母亲和婴儿免受流感感染。怀孕期间接种疫苗可以增强母体抗体，增加免疫球蛋白G从母体通过胎盘向胎儿的转移，从而保护年龄太小而不能接种疫苗的婴儿免受感染。来自临床试验和观察性研究的数据未证明接种流感疫苗对母亲、胎儿或婴儿有不良影响。我们目前的数据有效性和安全性流感疫苗接种在怀孕期间预防疾病的幼小婴儿。
The influenza virus circulates yearly and causes global epidemics. Influenza infection affects all age groups and causes mild to severe illness, and young infants are at particular risk for serious disease. The most effective measure to prevent influenza disease is vaccination; however, no vaccine is licensed for use in infants younger than 6 months old. Thus, there is a crucial need for other preventive strategies in this high-risk age group. Influenza vaccination during pregnancy protects both the mothers and the young infants against influenza infection. Vaccination during pregnancy boosts the maternal antibodies and increases the transfer of immunoglobulin G from the mother to the fetus through the placenta, which confers protection against infection in infants too young to be vaccinated. Data from clinical trials and observational studies did not demonstrate adverse effects to the mother, the fetus, or the infant after maternal influenza vaccination. We present the current data on the effectiveness and safety of influenza vaccination during pregnancy in preventing disease in the young infant.