Ferroxidase activity of rat ceruloplasmin.
Ferroxidase activity of rat ceruloplasmin.
复制标题
大鼠铜蓝蛋白的铁氧化酶活性。
DOI：
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发表时间：
1974
影响因子：
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通讯作者：
G. Cartwright
中科院分区：
文献类型：
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作者：
D. Williams;G. R. Lee;G. Cartwright
书名/作者声明：[by]J.大鼠铜蓝蛋白的FB-氧化还原活性。上午好。J.Physiol.227(5)：1094-1097。1974年的今天，在不同的测定条件下，研究了大鼠铜蓝蛋白的铁氧合酶活性。在不含抗坏血酸的醋酸盐缓冲溶液中，亚铁氧基酶的最适pH为6.0~6.2，约为人铜蓝蛋白的1/3和猪铜蓝蛋白的1/1。然而，低铜蓝蛋白血症大鼠出现低体温，注射铜蓝蛋白后血浆铁迅速升高。因此，在大鼠和猪体内，铜蓝蛋白似乎是铁从网状内皮细胞流向转铁蛋白所必需的。
WILLIAMS, ID. M., G. K. LEE, AND G. E CARTWRIGIIT. Fb-roxidasc nctivity of rat ccruloplasmin. Am. J. Physiol. 227(5) : 1094-1097. 1974.-The ferroxidase activity of rat ceruloplasmin was studied under various assay conditions. The ferroxidase activity was optimal at pH 6.0-6.2 in acetate buffer in the absence of ascorbate, and under these conditions the activity was about 1/3rd that of human ceruloplasmin and 1 /lOth that of porcine ceruloplasmin. However, hypoceruloplasmincmic rats developed hypofcrrcmia, and the administration of ceruloplasmin was followed by a prompt increase in plasma iron. Thus, ceruloplasmin appears to be essential for the flow of iron from reticuloendothelial cells to transferrin in the rat as well as the pig.