GENETIC DISSECTION OF SHORT-TERM AND LONG-TERM FACILITATION AT DROSOPHILA NEUROMUSCULAR-JUNCTION
GENETIC DISSECTION OF SHORT-TERM AND LONG-TERM FACILITATION AT DROSOPHILA NEUROMUSCULAR-JUNCTION
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DOI：
10.1073/pnas.75.1.515
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发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
JAN, LY
中科院分区：
文献类型：
--
作者：
JAN, YN;JAN, LY
果蝇幼虫神经肌肉连接处的递质释放可能因神经先前的活动而增加。这种促进现象至少涉及两个过程，一个是短期的，另一个是长期的。这些都是基于不同的机制，因为(i)发现一个突变体具有异常的长期促进作用，但短期促进作用正常；（ii）河豚毒素或去除外部Na+消除了长期促进作用，但短期促进作用无效。在长期促进中，由于每次神经刺激后突触前末端的Ca2+敏感性延长，递质释放延长。其原因可能是神经末梢内Na+的积累。
Transmitter release at the Drosophila larval neuromuscular junction may be increased by previous activity of the nerve. This facilitation phenomenon involves at least two processes, one short-term and other long-term. These are shown to based on different mechanisms because (i) a mutant was found that had abnormal long-term facilitation but normal short-term facilitation; and (ii) long-term facilitation was eliminated by tetrodotoxin or by removing external Na+ but short-term facilitation was not. In long-term facilitation, there was a prolonged release of transmitter due to a prolonged Ca2+ sensitivity of the presynaptic terminal after each nerve stimulus. The cause of this is probably accumulation of Na+ inside the nerve terminal.