Protocol for Morphological and Functional Phenotype Analysis of hiPS-Derived Cardiomyocytes
Protocol for Morphological and Functional Phenotype Analysis of hiPS-Derived Cardiomyocytes
复制标题
hiPS 衍生心肌细胞形态和功能表型分析方案
DOI：
10.1007/978-1-0716-1484-6_10
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Lee JK
中科院分区：
文献类型：
--
作者：
Li J;Lee JK
诱导多能干细胞(IPSCs)已被用于研究心脏疾病的生理发育和发病机制。IPS来源的心肌细胞和工程化心脏组织为研究心脏发育和疾病模型提供了一种很有前途的能力。除了用于心脏分化和3D心脏组织构建的方案外，建立用于综合评估iPS来源的细胞/组织的生理和/或病理生理学特性的方案是必不可少的。
Induced pluripotent stem cells (iPSCs) have been utilized to study physiological development and also the pathogenesis of heart diseases. iPS-derived cardiomyocytes and engineered cardiac tissues provide a promising capacity for investigating cardiac development and disease modeling. In addition to protocols for cardiac differentiation and 3D cardiac tissue construction, the establishment of protocols for the comprehensive evaluation of the physiological and/or pathophysiological properties for the iPS-derived cells/tissues are indispensable.