Echocardiography in Low-Risk Hypertensive Patients
Echocardiography in Low-Risk Hypertensive Patients
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DOI：
10.1161/jaha.119.013497
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发表时间：
2019-12-17
影响因子：
5.4
通讯作者：
Reboldi, Gianpaolo
中科院分区：
文献类型：
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作者：
Mancusi, Costantino;Angeli, Fabio;Reboldi, Gianpaolo
背景超声心动图是否应作为所有高血压患者诊断检查的一部分仍存在争议。我们确定了一些因素可能与左心室肥厚（LVH）在未经治疗的高血压patients.Methods和ResultsWe研究了2150例患者无LVH在ECG超声心动图。所有患者均接受标准12导联ECG和超声心动图检查。平均年龄为48.7岁，平均诊室血压为154/97 mm Hg。超声心动图左室肥厚（女性左室质量>47.0 g/m（2.7），男性>50.0 g/m（2.7））的患病率为37.1%。在多变量logistic回归分析的基础上，我们开发了一个基于7个项目（年龄、吸烟、体重指数、办公室收缩压和舒张压、康奈尔电压和慢性肾脏疾病）的列线图。我们通过自助重新校准对模型进行了内部验证，并获得了校准曲线，以评估验证数据集的一致性。超声心动图检查LVH的概率范围为≥ 180分）。LVH患者比例随总评分的增加而逐渐增加（卡方2 =444.8;女性P124）。
BackgroundIt is debated whether echocardiography should be part of the diagnostic workup in all hypertensive patients. We identified some factors potentially associated with left ventricular hypertrophy (LVH) at echocardiography in untreated hypertensive patients.Methods and ResultsWe studied 2150 patients without LVH at ECG. All patients underwent standard 12-lead ECG and echocardiography. Mean age was 48.7 years, and mean office blood pressure was 154/97 mm Hg. Prevalence of echocardiographic LVH (LV mass >47.0 g/m(2.7) in women and >50.0 g/m(2.7) in men) was 37.1%. We developed a nomogram based on 7 items (age, smoking, body mass index, office systolic and diastolic blood pressure, Cornell voltage, and chronic kidney disease) on the basis of a multivariable logistic regression analysis. We internally validated the model by bootstrap recalibration and obtained a calibration curve to assess agreement in the validation data set. Probability of LVH at echocardiography ranged from = 180 points). Proportion of patients with LVH progressively increased with the total score (chi(2)=444.8; P124 in women.