Prevention of blood transfusion with intravenous iron in gynecologic cancer patients receiving platinum-based chemotherapy
Prevention of blood transfusion with intravenous iron in gynecologic cancer patients receiving platinum-based chemotherapy
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DOI：
10.1016/j.ygyno.2013.09.028
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发表时间：
2013-12-01
影响因子：
4.7
通讯作者：
Sirisabya, Nakarin
中科院分区：
文献类型：
--
作者：
Athibovonsuk, Punnada;Manchana, Tarinee;Sirisabya, Nakarin
目标。比较静脉注射铁与口服铁预防妇科肿瘤患者接受铂类化疗后输血的效果。材料和方法。根据基线血红蛋白水平和化疗方案，对64例接受辅助铂类化疗的非贫血妇科癌症患者进行分层和随机化。研究组每次化疗后立即静脉注射蔗糖铁200mg。对照组口服富马酸亚铁200 mg，每日3次。每次化疗输注前监测全血细胞计数。血红蛋白水平低于10 mg/dl时给予输血。每组32例。两组之间的基线血红蛋白水平和基线特征无显著差异。研究组9例（28.1%）患者需要输血，对照组18例（56.3%）患者需要输血，共6个化疗周期（p = 0.02）。与对照组相比，研究组所需的红细胞总数中位数较少（分别为0和0.5个单位，p = 0.04）。严重不良事件及超敏反应未见报道。而对照组便秘发生率明显高于对照组(3.1%和40.6%,p =
Objectives. To compare the efficacy of intravenous iron and oral iron for prevention of blood transfusions in gynecologic cancer patients receiving platinum-based chemotherapy.Materials and methods. Sixty-four non anemic gynecologic cancer patients receiving adjuvant platinum-based chemotherapy were stratified and randomized according to baseline hemoglobin levels and chemotherapy regimen. The study group received 200 mg of intravenous iron sucrose immediately after each chemotherapy infusion. The control group received oral ferrous fumarate at a dose of 200 mg three times a day. Complete blood count was monitored before each chemotherapy infusion. Blood transfusions were given if hemoglobin level was below 10 mg/dl.Results. There were 32 patients in each group. No significant differences in baseline hemoglobin levels and baseline characteristics were demonstrated between both groups. Nine patients (28.1%) in the study group and 18 patients (56.3%) in the control group required blood transfusion through 6 cycles of chemotherapy (p = 0.02). Fewer median number of total packed red cell units were required in the study group compared to the control group (0 and 0.5 unit, respectively, p = 0.04). Serious adverse events and hypersensitivity reactions were not reported. However, constipation was significantly higher in the control group (3.1% and 40.6%, p =