Association of traditional and nontraditional cardiovascular risk factors with coronary artery calcification
Association of traditional and nontraditional cardiovascular risk factors with coronary artery calcification
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DOI：
10.1177/000331970405500602
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发表时间：
2004-11-01
期刊：
影响因子：
2.8
通讯作者：
Stillman, AE
中科院分区：
文献类型：
--
作者：
Folsom, AR;Evans, GW;Stillman, AE
冠状动脉钙化是一种新兴的冠状动脉粥样硬化标志物。作者研究了冠状动脉钙评分与传统和非传统心血管危险因素的关系。在1999-2000年间，他们测量了360名没有已知冠状动脉疾病的参与者的冠状动脉钙，这些参与者参加了社区动脉粥样硬化风险研究（ARIC）的两个中心。他们将冠状动脉钙评分与1987-1989年测量的危险因素联系起来。大多数传统的危险因素与冠状动脉钙评分有关。例如，多变量调整后的高评分（大于等于100比小于100）的优势比每10岁高3.5倍，男性比女性高3.2倍，糖尿病患者比女性高3.1倍（统计学上无显著性），血浆胆固醇和吸烟包年的增量每标准差高1.4- 1.7倍。颈动脉内膜-中膜厚度也与冠状动脉钙化呈正相关。相反，各种止血和炎症标志物以及血清化学值与钙评分无关。这些发现重申了传统危险因素在冠状动脉疾病病因学中的既定作用，通过计算机断层扫描进行了评估，但没有发现任何重要的非传统危险因素。
Coronary artery calcification assessed by computed tomography is an emerging marker of coronary atherosclerosis. The authors examined the association of coronary calcium scores with traditional and nontraditional cardiovascular risk factors. In 1999-2000, they measured coronary artery calcium in 360 participants free of known coronary artery disease who had participated in 2 centers of the Atherosclerosis Risk in Communities (ARIC) Study. They related coronary calcium scores to risk factors measured in 1987-1989. Most traditional risk factors were associated with the coronary calcium score. For example, the multivariately adjusted odds ratio for an elevated score ( greater than or equal to 100 versus < 100) was 3.5-fold greater per 10 years of age, 3.2-fold greater in men than in women, 3.1-fold greater with diabetes (statistically nonsignificant), and 1.4- to 1.7-fold greater per standard deviation greater increments of plasma cholesterol and pack-years of cigarettes smoked. Carotid artery intima-media thickness also was positively associated with coronary calcification. In contrast, a wide variety of hemostatic and inflammatory markers and serum chemistry values were unrelated to calcium scores. These findings reaffirmed the established role of traditional risk factors in the etiology of coronary artery disease, as assessed by computed tomography, but did not identify any important nontraditional risk factors.