Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men.
Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men.
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DOI：
10.1038/ncomms14146
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发表时间：
2017-01-30
影响因子：
16.6
通讯作者：
Carpentier AC
中科院分区：
文献类型：
--
作者：
Blondin DP;Tingelstad HC;Noll C;Frisch F;Phoenix S;Guérin B;Turcotte ÉE;Richard D;Haman F;Carpentier AC
在啮齿类动物中，棕色脂肪组织（BAT）在产生热量以抵御寒冷方面起着重要作用，并且可以代谢大量的膳食脂肪酸（DFA）。BAT在人类DFA代谢中的作用尚不清楚。在这里，我们表明，轻度冷刺激（18 °C）导致BAT相对于非冷适应男性的骨骼肌和白色脂肪组织显著更大的DFA提取分数，这些男性给予含有长链脂肪酸PET示踪剂14（R，S）-[18 F]-氟-6-硫杂十七烷酸（18 FTHA）的标准液体餐。然而，BAT对全身DFA清除的净贡献相对较小。尽管4周的冷驯化使BAT氧化代谢增加了2.6倍，但BAT DFA摄取没有进一步增加。这些发现表明，冷刺激的BAT可有助于从循环中清除DFA，但其贡献不如心脏、肝脏、骨骼肌或白色脂肪组织显著。棕色脂肪组织（BAT）吸收并燃烧脂肪酸以产热小鼠。在这里，作者使用PET表明，在人类中，冷刺激增加了BAT从血浆和氧化代谢中摄取的膳食脂肪酸，尽管与小鼠不同，人类BAT摄取的脂肪酸比其他代谢组织少。
In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue in non-cold-acclimated men given a standard liquid meal containing the long-chain fatty acid PET tracer, 14(R,S)-[18F]-fluoro-6-thia-heptadecanoic acid (18FTHA). However, the net contribution of BAT to systemic DFA clearance is comparatively small. Despite a 4-week cold acclimation increasing BAT oxidative metabolism 2.6-fold, BAT DFA uptake does not increase further. These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues. Brown adipose tissue (BAT) takes up and burns fatty acids for thermogenesis in mice. Here the authors use PET to show that, in humans, cold stimulation increases BAT dietary fatty acid uptake from plasma and oxidative metabolism, although, unlike mice, human BAT takes up less fatty acids than other metabolic tissues.