Gene therapy for the treatment of cancer.
Gene therapy for the treatment of cancer.
复制标题
用于治疗癌症的基因疗法。
DOI：
10.1089/108497801753131354
复制
发表时间：
2001
影响因子：
3.4
通讯作者：
Curiel,DT
中科院分区：
文献类型：
--
作者：
Buchsbaum,DJ;Curiel,DT
肿瘤形成的分子基础的描绘提供了通过基因治疗的特定干预的可能性，通过引入遗传物质用于治疗目的。在这方面，委员会注意到， 已经开发了几种用于治疗癌症的基因治疗方法：突变补偿、遗传免疫增强、分子化学疗法、抑制血管生成、复制载体 肿瘤溶解和化学增敏或放射增敏。临床试验已经开始，以评估安全性，毒性和有效性的每一个这些方法，基于有前途的临床前结果。 已经确定的各种限制包括缺乏载体的体内选择性肿瘤递送、治疗基因的最小表达、针对载体的免疫应答和正常组织毒性。 基因治疗与化疗或放疗的联合治疗已显示出良好的效果。预计随着新的治疗靶点和方法的确定， 随着载体设计的不断进步，基因治疗将在临床癌症治疗中发挥越来越大的作用。
The delineation of the molecular basis of neoplasia provides the possibility of specific intervention by gene therapy through the introduction of genetic material for therapeutic purposes. In this regard, several gene therapy approaches have been developed for the treatment of cancer: mutation compensation, genetic immunopotentiation, molecular chemotherapy, inhibition of angiogenesis, replicative vector oncolysis, and chemosensitization or radiosensitization. Clinical trials have been initiated to evaluate safety, toxicity, and efficacy of each of these approaches, based on promising preclinical results. Various limitations that have been identified include lack of in vivo selective tumor delivery of vectors, minimal expression of therapeutic genes, immune response against vectors, and normal tissue toxicity. Combined modality therapy with gene therapy and chemotherapy or radiation therapy has shown promising results. It is expected that as new therapeutic targets and approaches are identified, combined with advances in vector design, that gene therapy will play an increasing role in clinical cancer treatment.