Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide:: modification of the side chain
Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide:: modification of the side chain
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DOI：
10.1016/j.bmcl.2005.03.018
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发表时间：
2005-05-02
影响因子：
2.7
通讯作者：
Díaz, JF
中科院分区：
文献类型：
--
作者：
Paterson, I;Menche, D;Díaz, JF
通过分子建模设计了微管稳定抗癌剂laulimalide的新的简化类似物，包括具有非天然侧链的第一衍生物，通过后期多样化策略合成，并在体外评价了对人卵巢癌细胞系（A2780，A2780/AD 10）的生长抑制。(c)2005爱思唯尔有限公司保留所有权利。
Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10). (c) 2005 Elsevier Ltd. All rights reserved.