PREDISPOSITION TO RENAL-CELL CARCINOMA DUE TO ALTERATION OF A CANCER SUSCEPTIBILITY GENE
PREDISPOSITION TO RENAL-CELL CARCINOMA DUE TO ALTERATION OF A CANCER SUSCEPTIBILITY GENE
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DOI：
10.1126/science.1553556
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发表时间：
1992-03-27
期刊：
影响因子：
56.9
通讯作者：
EVERITT, J
中科院分区：
文献类型：
--
作者：
WALKER, C;GOLDSWORTHY, TL;EVERITT, J
在遗传性人类肾癌的啮齿类动物模型中，肿瘤易感位点的单个种系基因突变导致化学致癌的易感性增加了 70 倍。一种针对肾上皮细胞和间质细胞的致癌物质导致易感动物中上皮来源的肿瘤增加；致癌物诱发的间质肿瘤的数量不受易感位点突变的影响。因此，该突变定义了对致癌物诱导的肿瘤易感性的遗传位点，并且该位点对致癌物易感性的调节表现出细胞类型特异性。
A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.