Can faulty antennae increase adiposity? The link between cilia proteins and obesity.
Can faulty antennae increase adiposity? The link between cilia proteins and obesity.
复制标题
DOI：
10.1677/joe-09-0116
复制
发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
P. S. Sen Gupta;Natalia V. Prodromou;J. Chapple
中科院分区：
文献类型：
--
作者：
P. S. Sen Gupta;Natalia V. Prodromou;J. Chapple
初级纤毛是大多数哺乳动物细胞表面突出的感觉细胞器。在人类和小鼠中，正常纤毛功能所需的蛋白质突变已被确定为引起一类具有重叠表型的疾病，称为纤毛病。最近的证据表明，纤毛病的肥胖与下丘脑能量稳态的调节和脂肪形成有关。本文考虑纤毛在这些过程中的作用，以及纤毛功能障碍是否可能与更常见的肥胖形式有关。
Primary cilia are sensory organelles that protrude from the surface of most mammalian cell types. In humans and mice, mutations in proteins required for normal cilia function have been identified as causing a class of disorders with overlapping phenotypes known as ciliopathies. Recent evidence has linked obesity in ciliopathies to both the regulation of energy homeostasis in the hypothalamus and to adipogenesis. This article considers the role of cilia in these processes and whether cilia dysfunction may be relevant to more common forms of obesity.