Prebiotic effects of almonds and almond skins on intestinal microbiota in healthy adult humans
Prebiotic effects of almonds and almond skins on intestinal microbiota in healthy adult humans
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DOI：
10.1016/j.anaerobe.2013.11.007
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发表时间：
2014-04-01
期刊：
影响因子：
2.3
通讯作者：
Ni, Li
中科院分区：
文献类型：
--
作者：
Liu, Zhibin;Lin, Xiuchun;Ni, Li
杏仁和杏仁皮富含纤维和其他具有潜在益生元特性的成分。在这项研究中，我们调查了健康人摄入杏仁和杏仁皮的益生元效应。共有48名健康成年志愿者每天食用烤杏仁（56 g），杏仁皮（10 g）或商业低聚果糖（8 g）（作为阳性对照），持续6周。在规定的时间点收集粪便样品，并分析微生物群组成和选定的微生物活性指标。不同菌株的肠道细菌对杏仁或杏仁皮有不同程度的生长敏感性。双歧杆菌属的数量显著增加。和乳杆菌属。作为杏仁或杏仁皮补充剂的结果，在粪便样品中观察到。然而，大肠杆菌的种群没有显着变化，而病原体产气荚膜梭菌的生长显着抑制。肠道微生物群组成的改变诱导细菌酶活性的变化，特别是粪便β-半乳糖苷酶活性的显著增加和粪便β-葡萄糖醛酸酶、硝基还原酶和偶氮还原酶活性的降低。我们的观察结果表明，杏仁和杏仁皮的摄入可能会导致肠道微生物群的改善和肠道细菌活动的改变，这将促进健康有益因素和抑制有害因素。因此，我们相信杏仁和杏仁皮具有潜在的益生元特性。(C)2013爱思唯尔有限公司版权所有。
Almonds and almond skins are rich in fiber and other components that have potential prebiotic properties. In this study we investigated the prebiotic effects of almond and almond skin intake in healthy humans. A total of 48 healthy adult volunteers consumed a daily dose of roasted almonds (56 g), almond skins (10 g), or commercial fructooligosaccharides (8 g) (as positive control) for 6 weeks. Fecal samples were collected at defined time points and analyzed for microbiota composition and selected indicators of microbial activity. Different strains of intestinal bacteria had varying degrees of growth sensitivity to almonds or almond skins. Significant increases in the populations of Bifidobacterium spp. and Lactobacillus spp. were observed in fecal samples as a consequence of almond or almond skin supplementation. However, the populations of Escherichia coli did not change significantly, while the growth of the pathogen Clostridum perfringens was significantly repressed. Modification of the intestinal microbiota composition induced changes in bacterial enzyme activities, specifically a significant increase in fecal beta-galactosidase activity and decreases in fecal beta-glucuronidase, nitroreductase and azoreductase activities. Our observations suggest that almond and almond skin ingestion may lead to an improvement in the intestinal microbiota profile and a modification of the intestinal bacterial activities, which would induce the promotion of health beneficial factors and the inhibition of harmful factors. Thus we believe that almonds and almond skins possess potential prebiotic properties. (C) 2013 Elsevier Ltd. All rights reserved.