Inferring cellular networks--a review.
Inferring cellular networks--a review.
复制标题
推断蜂窝网络——回顾。
DOI：
10.1186/1471-2105-8-s6-s5
复制
发表时间：
2007-09-27
影响因子：
3
通讯作者：
Spang, Rainer
中科院分区：
文献类型：
--
作者：
Markowetz, Florian;Spang, Rainer
在这篇综述中，我们给出了一个概述的计算和统计方法来重建细胞网络。虽然这一领域的研究是巨大的，快速发展，我们表明，目前使用的方法可以组织的几个关键概念。回顾的第一部分涉及条件独立模型，包括高斯图模型和贝叶斯网络。第二部分讨论了实验干预和扰动数据的概率和基于图形的方法。
In this review we give an overview of computational and statistical methods to reconstruct cellular networks. Although this area of research is vast and fast developing, we show that most currently used methods can be organized by a few key concepts. The first part of the review deals with conditional independence models including Gaussian graphical models and Bayesian networks. The second part discusses probabilistic and graph-based methods for data from experimental interventions and perturbations.