Interneurones are not so dormant in temporal lobe epilepsy: a critical reappraisal of the dormant basket cell hypothesis
Interneurones are not so dormant in temporal lobe epilepsy: a critical reappraisal of the dormant basket cell hypothesis
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DOI：
10.1016/s0920-1211(98)00043-6
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发表时间：
1998-09-01
影响因子：
2.2
通讯作者：
Bernard, C
中科院分区：
文献类型：
--
作者：
Bernard, C;Esclapez, M;Bernard, C
癫痫研究的基础之一是兴奋和抑制之间存在不平衡。这种异常可以通过增加对主细胞的兴奋、减少抑制（即去抑制）或两者来实现。这篇评论的重点是功能障碍的抑制，特别是在“休眠篮细胞假说”。这一假说认为：（1）中间神经元在功能上与兴奋性传入神经元分离，导致主神经元的过度兴奋和成对脉冲抑制的丧失;（2）当适当激活时，中间神经元仍然可以执行其任务，即抑制癫痫样活动并恢复成对脉冲抑制。这篇综述的目的是讨论支持“休眠篮细胞假说”的证据。我们将首先讨论假设的基本原理和验证假设所需的标准。然后，我们将展示，（1）支持假设的关键实验数据（Bekenstein和Lothman，1993年）。颞叶癫痫模型中抑制性中间神经元的休眠。Science 259，97-100; Sloviter，1991.大鼠实验性癫痫持续状态后海马结构、兴奋性和抑制性的永久性改变：“休眠篮细胞”假说及其与颞叶癫痫的相关性。海马1，41-66）是难以解释的，（2）最近的记录，从间神经元在癫痫组织反对的假设。“休眠篮细胞假说”，然后讨论在更广泛的背景下去抑制。(C)1998 Elsevier Science B. V.保留所有权利。
One axiom at the basis of epilepsy research is that there exists an imbalance between excitation and inhibition. This abnormality can be achieved by an increase of excitation on principal cells, a decreased inhibition (i.e. disinhibition) or both. This review focuses on dysfunction of inhibition, and in particular on the 'dormant basket cell hypothesis'. This hypothesis states that, (1) interneurones are functionally disconnected from excitatory afferents, resulting in hyperexcitability of principal neurones and loss of paired pulse inhibition, (2) when properly activated, interneurones can still perform their task, i.e. suppress epileptiform activity and restore paired pulse inhibition. The aim of this review is to discuss the evidence in support of the 'dormant basket cell hypothesis'. We will first discuss the rationale underlying the hypothesis and the criteria needed to validate the hypothesis. We will then show that, (1) the key experimental data offered in support of the hypothesis (Bekenstein and Lothman, 1993. Dormancy of inhibitory interneurones in a model of temporal lobe epilepsy. Science 259, 97-100; Sloviter, 1991. Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: the 'dormant basket cell' hypothesis and its relevance to temporal lobe epilepsy. Hippocampus 1, 41-66) are difficult to interpret, and (2) recent recordings from interneurones in epileptic tissue argue against the hypothesis. The 'dormant basket cell hypothesis' is then discussed in the broader context of disinhibition. (C) 1998 Elsevier Science B.V. All rights reserved.