DIFFERENTIATION OF CEREBRAL DENDRITES - A STUDY OF POST-MIGRATORY NEUROBLAST IN MEDIAL NUCLEUS OF TRAPEZOID BODY
DIFFERENTIATION OF CEREBRAL DENDRITES - A STUDY OF POST-MIGRATORY NEUROBLAST IN MEDIAL NUCLEUS OF TRAPEZOID BODY
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DOI：
10.1007/bf00522528
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发表时间：
1969-01-01
期刊：
影响因子：
--
通讯作者：
MOREST, DK
中科院分区：
文献类型：
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作者：
MOREST, DK
在内侧斜方核的负鼠和猫的树突的分化已被跟踪从阶段的迁移后的神经母细胞的发展系列准备与快速高尔基体技术。迁移后的神经母细胞是一个细长的细胞。其核周体最初位于髓质的外界层。它的原始内突生长成原始内侧斜方核并产生轴突。在邻近轴突起源的成神经细胞部分，传入轴突的末梢开始分化。核周体通过原始的内突移动到成神经细胞的同一部位。随后树突分化。树突和它们的分支从萌芽的生长锥形成。年轻生长神经元的胞体和树突状突起被暂时的丝状伪足覆盖。萌芽生长锥和丝状伪足出现在延长和扩大的树突的尖端和沿着轴。生长锥的运动和合成活动建立了每种神经元的定型树突分支模式。树突分支的发育伴随着特定类型的轴突丛的发育，轴突丛将成为突触相关的。这表明树突树和传入轴突终支的模式来自生长的树突和轴突分支的相互作用。这些相互作用可以通过物理接触以及趋化因子介导。丝状伪足与树枝状附属物的形成有关。丝状伪足可以参与膜合成、运动和突触发生。有迹象表明，传入轴突可以诱导成神经细胞的突触后部分的分化。这些结果表明，物理和化学因素对脑突触组织分化的影响取决于它们的时间和空间顺序。
The differentiation of dendrites in the medial trapezoid nucleus of the opossum and cat has been traced from the stage of the post-migratory neuroblast in developmental series prepared with the rapid Golgi technique. The post-migratory neuroblast is an elongated cell. Its perikaryon is located initially at the outer limiting layer of the medulla. Its primitive internal process grows into the primordial medial trapezoid nucleus and gives rise to an axon. On the part of the neuroblast adjacent to the axon's origin the endings of the afferent axons beging to differentiate. The perikaryon moves to the same part of the neuroblast through the primitive internal process. Subsequently the dendrites differentiate. Dendrites and their branches form from budding growth cones. The cell body and dendritic processes of the young growing neuron are covered with transitory filopodia. Sprouting growth cones and filopodia appear at the tips and along the shafts of the elongating and enlarging dendrites. The locomotor and synthetic activities of the growth cones establish the stereotyped dendritic branching patterns of each kind of neuron. The development of the dendritic branches accompanies the elaboration of the particular type of axonal plexus that will become synaptically related. This suggests that the patterns of the dendritic trees and of the afferent axonal end-branches derive from mutual interactions of the growing dendritic and axonal branches. These interactions may be mediated by physical contacts as well as chemotactic factors. The filopodia are implicated in the formation of dendritic appendages. Filopodia could participate in membrane synthesis, locomotion, and synaptogenesis. There is an indication that the afferent axons can induce the differentiation of the post-synaptic parts of the neuroblast. The findings imply that the influence of physical and chemical factors in the differentiation of the synaptic organization of the brain depends on their temporal and spatial sequences.