Totally transparent hydrogel-based subdural electrode with patterned salt bridge
Totally transparent hydrogel-based subdural electrode with patterned salt bridge
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DOI：
10.1007/s10544-020-00517-0
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发表时间：
2020-08
影响因子：
2.8
通讯作者：
Ayaka Nishimura;Ryota Suwabe;Yuka Ogihara;S. Yoshida;H. Abe;S. Osawa;A. Nakagawa;T. Tominaga;M. Nishizawa
中科院分区：
文献类型：
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作者：
Ayaka Nishimura;Ryota Suwabe;Yuka Ogihara;S. Yoshida;H. Abe;S. Osawa;A. Nakagawa;T. Tominaga;M. Nishizawa
通过将由聚二甲基硅氧烷（PDMS）制成的导电聚乙烯醇（PVA）填充微通道嵌入另一种聚乙烯醇水凝胶基质中，开发出一种全透明硬膜下电极。PVA衬底和PDMS微通道（盐桥）之间的紧密结合是通过利用微通道上形成的微突起的机械联锁实现的。这种简单的粘合方法不使用任何添加剂，如硅烷分子或纳米纤维，非常适合用于构建生物医学设备。盐桥电极（总厚度约1.5 mm）足够柔软，并且显示出优异的形状一致性，使其成为脑表面硬膜下电极的绝佳选择。体内测量证明，盐桥电极与暴露在外的猪脑紧密接触，可记录频率为1 ~ 15 Hz的脑电波信号。此外，电极的高透明度提供了清晰的脑表面视图，这将有助于有效的外科手术和光遗传学研究。
A totally transparent subdural electrode was developed by embedding a conductive poly (vinyl alcohol) (PVA)-filled microchannel made of poly(dimethylsiloxane) (PDMS) into an another PVA hydrogel substrate. Tight bonding between the PVA substrate and the PDMS microchannel (salt bridge) was achieved by mechanical interlocking utilizing the microprotrusions formed on the microchannel. This simple method of bonding without the use of any additives such as silane molecules or nanofibers is very suitable for constructing biomedical devices. The salt bridge electrode (total thickness, ca. 1.5 mm) was sufficiently soft, and showed superior shape conformability that makes it an excellent choice as a subdural electrode used on the brain surface. In vivo measurement proved that the salt bridge electrode makes close contact to the exposed porcine brain and can record brain wave signals of frequencies 1 ~ 15 Hz. In addition, the high transparency of the electrode provided a clear view of the brain surface that would assist the effective surgical operation and optogenetic research.